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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.
Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R. Xu Y, et al. Among authors: floege j. Nat Genet. 2022 Nov;54(11):1690-1701. doi: 10.1038/s41588-022-01202-z. Epub 2022 Oct 27. Nat Genet. 2022. PMID: 36303074 Free PMC article.
A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis.
Ostendorf T, van Roeyen CR, Peterson JD, Kunter U, Eitner F, Hamad AJ, Chan G, Jia XC, Macaluso J, Gazit-Bornstein G, Keyt BA, Lichenstein HS, LaRochelle WJ, Floege J. Ostendorf T, et al. Among authors: floege j. J Am Soc Nephrol. 2003 Sep;14(9):2237-47. doi: 10.1097/01.asn.0000083393.00959.02. J Am Soc Nephrol. 2003. PMID: 12937299
Complement C5 mediates experimental tubulointerstitial fibrosis.
Boor P, Konieczny A, Villa L, Schult AL, Bücher E, Rong S, Kunter U, van Roeyen CR, Polakowski T, Hawlisch H, Hillebrandt S, Lammert F, Eitner F, Floege J, Ostendorf T. Boor P, et al. Among authors: floege j. J Am Soc Nephrol. 2007 May;18(5):1508-15. doi: 10.1681/ASN.2006121343. Epub 2007 Mar 27. J Am Soc Nephrol. 2007. PMID: 17389734
Pro-fibrogenic potential of PDGF-D in liver fibrosis.
Borkham-Kamphorst E, van Roeyen CR, Ostendorf T, Floege J, Gressner AM, Weiskirchen R. Borkham-Kamphorst E, et al. Among authors: floege j. J Hepatol. 2007 Jun;46(6):1064-74. doi: 10.1016/j.jhep.2007.01.029. Epub 2007 Feb 23. J Hepatol. 2007. PMID: 17397961
765 results