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Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.
Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM. Silva LM, et al. Among authors: flick mj. Science. 2021 Dec 24;374(6575):eabl5450. doi: 10.1126/science.abl5450. Epub 2021 Dec 24. Science. 2021. PMID: 34941394
A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.
Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH. Motley MP, et al. Among authors: flick mj. Blood. 2016 Mar 3;127(9):1085-96. doi: 10.1182/blood-2015-05-644260. Epub 2015 Dec 8. Blood. 2016. PMID: 26647393 Free PMC article.
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA.
Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ. Juang LJ, et al. Among authors: flick mj. Blood. 2022 Mar 3;139(9):1302-1311. doi: 10.1182/blood.2021014559. Blood. 2022. PMID: 34958662 Free PMC article.
Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state.
Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Leung J, Zhao P, López DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML. Hernandez GE, et al. Among authors: flick mj. Nat Cardiovasc Res. 2022 Jan;1(1):67-84. doi: 10.1038/s44161-021-00006-4. Epub 2022 Jan 12. Nat Cardiovasc Res. 2022. PMID: 35599984 Free PMC article.
111 results