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aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability.
Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher T, Ebnet K, Potente M, Hirose T, Ohno S, Fleming I, Gattenlöhner S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M. Riddell M, et al. Among authors: fleming i. Nat Commun. 2018 Dec 17;9(1):5357. doi: 10.1038/s41467-018-07739-0. Nat Commun. 2018. PMID: 30559384 Free PMC article.
Cytochrome P450 2C is an EDHF synthase in coronary arteries.
Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R. Fisslthaler B, et al. Among authors: fleming i. Nature. 1999 Sep 30;401(6752):493-7. doi: 10.1038/46816. Nature. 1999. PMID: 10519554
The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.
Rezende F, Moll F, Walter M, Helfinger V, Hahner F, Janetzko P, Ringel C, Weigert A, Fleming I, Weissmann N, Kuenne C, Looso M, Rieger MA, Nawroth P, Fleming T, Brandes RP, Schröder K. Rezende F, et al. Among authors: fleming t, fleming i. Redox Biol. 2018 May;15:12-21. doi: 10.1016/j.redox.2017.11.014. Epub 2017 Nov 22. Redox Biol. 2018. PMID: 29195137 Free PMC article.
Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells.
Cencioni C, Spallotta F, Savoia M, Kuenne C, Guenther S, Re A, Wingert S, Rehage M, Sürün D, Siragusa M, Smith JG, Schnütgen F, von Melchner H, Rieger MA, Martelli F, Riccio A, Fleming I, Braun T, Zeiher AM, Farsetti A, Gaetano C. Cencioni C, et al. Among authors: fleming i. Nat Commun. 2018 Mar 29;9(1):1281. doi: 10.1038/s41467-018-03668-0. Nat Commun. 2018. PMID: 29599503 Free PMC article.
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP. Hitzel J, et al. Among authors: fleming i. Nat Commun. 2018 Jun 12;9(1):2292. doi: 10.1038/s41467-018-04602-0. Nat Commun. 2018. PMID: 29895827 Free PMC article.
Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.
Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. Iring A, et al. Among authors: fleming i. J Clin Invest. 2019 Jun 17;129(7):2775-2791. doi: 10.1172/JCI123825. eCollection 2019 Jun 17. J Clin Invest. 2019. PMID: 31205027 Free PMC article.
615 results