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Designed High-Redox Potential Laccases Exhibit High Functional Diversity.
Barber-Zucker S, Mateljak I, Goldsmith M, Kupervaser M, Alcalde M, Fleishman SJ. Barber-Zucker S, et al. Among authors: fleishman sj. ACS Catal. 2022 Nov 4;12(21):13164-13173. doi: 10.1021/acscatal.2c03006. Epub 2022 Oct 13. ACS Catal. 2022. PMID: 36366766 Free PMC article.
Designed active-site library reveals thousands of functional GFP variants.
Weinstein JY, Martí-Gómez C, Lipsh-Sokolik R, Hoch SY, Liebermann D, Nevo R, Weissman H, Petrovich-Kopitman E, Margulies D, Ivankov D, McCandlish DM, Fleishman SJ. Weinstein JY, et al. Among authors: fleishman sj. Nat Commun. 2023 May 20;14(1):2890. doi: 10.1038/s41467-023-38099-z. Nat Commun. 2023. PMID: 37210560 Free PMC article.
Assessing and enhancing foldability in designed proteins.
Listov D, Lipsh-Sokolik R, Rosset S, Yang C, Correia BE, Fleishman SJ. Listov D, et al. Among authors: fleishman sj. Protein Sci. 2022 Sep;31(9):e4400. doi: 10.1002/pro.4400. Protein Sci. 2022. PMID: 36040259 Free PMC article.
Computationally designed hyperactive Cas9 enzymes.
Vos PD, Rossetti G, Mantegna JL, Siira SJ, Gandadireja AP, Bruce M, Raven SA, Khersonsky O, Fleishman SJ, Filipovska A, Rackham O. Vos PD, et al. Among authors: fleishman sj. Nat Commun. 2022 May 31;13(1):3023. doi: 10.1038/s41467-022-30598-9. Nat Commun. 2022. PMID: 35641498 Free PMC article.
What Have We Learned from Design of Function in Large Proteins?
Khersonsky O, Fleishman SJ. Khersonsky O, et al. Among authors: fleishman sj. Biodes Res. 2022 Mar 8;2022:9787581. doi: 10.34133/2022/9787581. eCollection 2022. Biodes Res. 2022. PMID: 37850148 Free PMC article. Review.
128 results