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Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis.
Ronner L, Podoltsev N, Gotlib J, Heaney ML, Kuykendall AT, O'Connell C, Shammo J, Fleischman AG, Scherber RM, Mesa R, Yacoub A, Perkins C, Meckstroth S, Behlman L, Chiaramonte M, Salehi M, Ziadkhanpour K, Nguyen H, Siwoski O, Hung AK, Janania Martinez M, Nguyen J, Patel S, Kollipara R, Dave A, Randall M, Grant M, Harrison M, Fernandez Soto P, Tremblay D, Hoffman R, Moshier E, Mascarenhas J. Ronner L, et al. Among authors: fleischman ag. Blood. 2020 May 7;135(19):1696-1703. doi: 10.1182/blood.2019003347. Blood. 2020. PMID: 32107559 Free PMC article.
Causal role for JAK2 V617F in thrombosis.
Fleischman AG, Tyner JW. Fleischman AG, et al. Blood. 2013 Nov 28;122(23):3705-6. doi: 10.1182/blood-2013-10-531665. Blood. 2013. PMID: 24288407 Free PMC article.
The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells.
Craver BM, Nguyen TK, Nguyen J, Nguyen H, Huynh C, Morse SJ, Fleischman AG. Craver BM, et al. Among authors: fleischman ag. Exp Hematol Oncol. 2020 Jan 2;9:1. doi: 10.1186/s40164-019-0157-6. eCollection 2020. Exp Hematol Oncol. 2020. PMID: 31908904 Free PMC article.
ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial.
Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O'Connell C, Arcasoy MO, Zhang Y, Kawashima J, Ganz T, Kowalski M, Brachmann CB. Oh ST, et al. Among authors: fleischman ag. Blood Adv. 2020 Sep 22;4(18):4282-4291. doi: 10.1182/bloodadvances.2020002662. Blood Adv. 2020. PMID: 32915978 Free PMC article. Clinical Trial.
Ruxolitinib discontinuation in polycythemia vera: Patient characteristics, outcomes, and salvage strategies from a large multi-institutional database.
Tremblay D, Ronner L, Podoltsev N, Gotlib J, Heaney M, Kuykendall A, O'Connell C, Shammo JM, Fleischman A, Mesa R, Yacoub A, Hoffman R, Moshier E, Zubizarreta N, Mascarenhas J. Tremblay D, et al. Leuk Res. 2021 Oct;109:106629. doi: 10.1016/j.leukres.2021.106629. Epub 2021 May 27. Leuk Res. 2021. PMID: 34082375
Anagrelide for platelet-directed cytoreduction in polycythemia vera: Insights into utility and safety outcomes from a large multi-center database.
Rippel N, Tremblay D, Zubizarreta N, Podoltsev N, Gotlib J, Heaney M, Kuykendall A, O'Connell C, Shammo JM, Fleischman A, Kremyanskaya M, Hoffman R, Mesa R, Yacoub A, Mascarenhas J. Rippel N, et al. Leuk Res. 2022 Aug;119:106903. doi: 10.1016/j.leukres.2022.106903. Epub 2022 Jun 16. Leuk Res. 2022. PMID: 35717689
47 results