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Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype.
Wesseler F, Lohmann S, Riege D, Halver J, Roth A, Pichlo C, Weber S, Takamiya M, Müller E, Ketzel J, Flegel J, Gihring A, Rastegar S, Bertrand J, Baumann U, Knippschild U, Peifer C, Sievers S, Waldmann H, Schade D. Wesseler F, et al. Among authors: flegel j. J Med Chem. 2022 Nov 24;65(22):15263-15281. doi: 10.1021/acs.jmedchem.2c01199. Epub 2022 Nov 8. J Med Chem. 2022. PMID: 36346705
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schröder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K. Němec V, et al. Among authors: flegel j. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066. doi: 10.1002/anie.201810312. Epub 2018 Dec 20. Angew Chem Int Ed Engl. 2019. PMID: 30569600
Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß.
Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H. Kremer L, et al. Among authors: flegel j. Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16617-16628. doi: 10.1002/anie.201907632. Epub 2019 Oct 4. Angew Chem Int Ed Engl. 2019. PMID: 31454140 Free PMC article. Review.
The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation.
Flegel J, Shaaban S, Jia ZJ, Schulte B, Lian Y, Krzyzanowski A, Metz M, Schneidewind T, Wesseler F, Flegel A, Reich A, Brause A, Xue G, Zhang M, Dötsch L, Stender ID, Hoffmann JE, Scheel R, Janning P, Rastinejad F, Schade D, Strohmann C, Antonchick AP, Sievers S, Moura-Alves P, Ziegler S, Waldmann H. Flegel J, et al. J Med Chem. 2022 Dec 22;65(24):16268-16289. doi: 10.1021/acs.jmedchem.2c00956. Epub 2022 Dec 2. J Med Chem. 2022. PMID: 36459434 Free PMC article.
A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway.
Liu J, Zhang R, Mallick S, Patil S, Wientjens C, Flegel J, Krupp A, Strohmann C, Grassin C, Merten C, Pahl A, Grigalunas M, Waldmann H. Liu J, et al. Among authors: flegel j. Chem Sci. 2023 Jun 21;14(29):7936-7943. doi: 10.1039/d3sc01240a. eCollection 2023 Jul 26. Chem Sci. 2023. PMID: 37502335 Free PMC article.
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