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Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent.
Holmes SE, Bachran C, Fuchs H, Weng A, Melzig MF, Flavell SU, Flavell DJ. Holmes SE, et al. Among authors: flavell su, flavell dj. Immunopharmacol Immunotoxicol. 2015 Feb;37(1):42-55. doi: 10.3109/08923973.2014.971964. Epub 2014 Oct 27. Immunopharmacol Immunotoxicol. 2015. PMID: 25347443
Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells.
Smith WS, Baker EJ, Holmes SE, Koster G, Hunt AN, Johnston DA, Flavell SU, Flavell DJ. Smith WS, et al. Among authors: flavell dj. Biochim Biophys Acta Biomembr. 2017 May;1859(5):993-1007. doi: 10.1016/j.bbamem.2017.02.013. Epub 2017 Feb 21. Biochim Biophys Acta Biomembr. 2017. PMID: 28235471 Free article.
60 results