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LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.
Li N, Rivéra-Bermúdez MA, Zhang M, Tejada J, Glasson SS, Collins-Racie LA, Lavallie ER, Wang Y, Chang KC, Nagpal S, Morris EA, Flannery CR, Yang Z. Li N, et al. Among authors: flannery cr. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9. doi: 10.1073/pnas.0911377107. Epub 2010 Feb 3. Proc Natl Acad Sci U S A. 2010. PMID: 20133709 Free PMC article.
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.
Collins-Racie LA, Flannery CR, Zeng W, Corcoran C, Annis-Freeman B, Agostino MJ, Arai M, DiBlasio-Smith E, Dorner AJ, Georgiadis KE, Jin M, Tan XY, Morris EA, LaVallie ER. Collins-Racie LA, et al. Among authors: flannery cr. Matrix Biol. 2004 Jul;23(4):219-30. doi: 10.1016/j.matbio.2004.05.004. Matrix Biol. 2004. PMID: 15296936
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, Flannery CR, Kanki K, Wang E, Peluso D, Yang Z, Majumdar MK, Morris EA. Glasson SS, et al. Among authors: flannery cr. Arthritis Rheum. 2004 Aug;50(8):2547-58. doi: 10.1002/art.20558. Arthritis Rheum. 2004. PMID: 15334469 Free article.
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor.
Chockalingam PS, Sun W, Rivera-Bermudez MA, Zeng W, Dufield DR, Larsson S, Lohmander LS, Flannery CR, Glasson SS, Georgiadis KE, Morris EA. Chockalingam PS, et al. Among authors: flannery cr. Osteoarthritis Cartilage. 2011 Mar;19(3):315-23. doi: 10.1016/j.joca.2010.12.004. Epub 2010 Dec 14. Osteoarthritis Cartilage. 2011. PMID: 21163358 Free article.
73 results