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Wnt Signaling in Cancer: Not a Binary ON:OFF Switch.
Flanagan DJ, Vincan E, Phesse TJ. Flanagan DJ, et al. Cancer Res. 2019 Dec 1;79(23):5901-5906. doi: 10.1158/0008-5472.CAN-19-1362. Epub 2019 Aug 20. Cancer Res. 2019. PMID: 31431458 Review.
PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.
Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. Sakthianandeswaren A, et al. Among authors: flanagan dj. Cancer Res. 2011 May 15;71(10):3709-19. doi: 10.1158/0008-5472.CAN-10-2342. Epub 2011 May 10. Cancer Res. 2011. PMID: 21558389 Free article.
Intestinal epithelial-specific PTEN inactivation results in tumor formation.
Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM. Byun DS, et al. Among authors: flanagan dj. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G856-64. doi: 10.1152/ajpgi.00178.2011. Epub 2011 Aug 11. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21836055 Free PMC article.
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.
Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M. Phesse TJ, et al. Among authors: flanagan dj. Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411. Sci Signal. 2014. PMID: 25270258 Free article.
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.
Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E. Flanagan DJ, et al. Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16. Stem Cell Reports. 2015. PMID: 25892522 Free PMC article.
44 results