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Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Prior H, Baldrick P, Beken S, Booler H, Bower N, Brooker P, Brown P, Burlinson B, Burns-Naas LA, Casey W, Chapman M, Clarke D, de Haan L, Doehr O, Downes N, Flaherty M, Gellatly N, Moesgaard SG, Harris J, Holbrook M, Hui J, Jones D, Jones K, Kedar H, Mahl A, Manninen A, McGuire A, Mortimer-Cassen E, Peraza M, Pugsley MK, Richard J, Roberts R, Roosen W, Rothfuss A, Schoenmakers A, Sewell F, Weaver R, Weir L, Wolfreys A, Kimber I. Prior H, et al. Among authors: flaherty m. Regul Toxicol Pharmacol. 2020 Jun;113:104624. doi: 10.1016/j.yrtph.2020.104624. Epub 2020 Feb 29. Regul Toxicol Pharmacol. 2020. PMID: 32126256 Free article.
Erratum to: An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability.
Wolf B, Jeliazkova-Mecheva V, Del Rio-Espinola A, Boisclair J, Walker D, Cochin De Billy B, Flaherty M, Flandre T. Wolf B, et al. Among authors: flaherty m. Toxicol Sci. 2022 Jan 24;185(2):246. doi: 10.1093/toxsci/kfab146. Toxicol Sci. 2022. PMID: 34905057 No abstract available.
Development of Anti-CD32b Antibodies with Enhanced Fc Function for the Treatment of B and Plasma Cell Malignancies.
Lu H, Molony RD, Chen D, Jang S, Wolf B, Ewert S, Flaherty M, Xu F, Isim S, Shim Y, Dornelas C, Balke N, Leber XC, Scharenberg M, Koelln J, Choi E, Ward R, Johnson J, Calzascia T, Isnardi I, Williams JA, Lindenbergh PL, van de Donk NWCJ, Mutis T, Huet H, Lees E, Meyer MJ. Lu H, et al. Among authors: flaherty m. Mol Cancer Ther. 2020 Oct;19(10):2089-2104. doi: 10.1158/1535-7163.MCT-19-0003. Epub 2020 Aug 26. Mol Cancer Ther. 2020. PMID: 32847974
Heterogeneity of toxicant response: sources of human variability.
Aldridge JE, Gibbons JA, Flaherty MM, Kreider ML, Romano JA, Levin ED. Aldridge JE, et al. Among authors: flaherty mm. Toxicol Sci. 2003 Nov;76(1):3-20. doi: 10.1093/toxsci/kfg204. Epub 2003 Jul 25. Toxicol Sci. 2003. PMID: 12883075 Review.
23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity.
Proia T, Jiang F, Bell A, Nicoletti R, Kong L, Kreuter K, Poling L, Winston WM, Flaherty M, Weiler S, Perino S, O'Hagan R, Lin J, Gyuris J, Okamura H. Proia T, et al. Among authors: flaherty m. Mol Cancer Ther. 2015 Aug;14(8):1858-67. doi: 10.1158/1535-7163.MCT-14-1104. Epub 2015 May 20. Mol Cancer Ther. 2015. PMID: 25995436
Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.
Bialucha CU, Collins SD, Li X, Saxena P, Zhang X, Dürr C, Lafont B, Prieur P, Shim Y, Mosher R, Lee D, Ostrom L, Hu T, Bilic S, Rajlic IL, Capka V, Jiang W, Wagner JP, Elliott G, Veloso A, Piel JC, Flaherty MM, Mansfield KG, Meseck EK, Rubic-Schneider T, London AS, Tschantz WR, Kurz M, Nguyen D, Bourret A, Meyer MJ, Faris JE, Janatpour MJ, Chan VW, Yoder NC, Catcott KC, McShea MA, Sun X, Gao H, Williams J, Hofmann F, Engelman JA, Ettenberg SA, Sellers WR, Lees E. Bialucha CU, et al. Among authors: flaherty mm. Cancer Discov. 2017 Sep;7(9):1030-1045. doi: 10.1158/2159-8290.CD-16-1414. Epub 2017 May 19. Cancer Discov. 2017. PMID: 28526733
Impact of Poverty on Stroke Recurrence: A Population-Based Study.
Becker CJ, Sucharew H, Robinson D, Stamm B, Royan R, Nobel L, Stanton RJ, Jasne AS, Woo D, De Los Rios La Rosa F, Mackey J, Ferioli S, Mistry EA, Demel S, Haverbusch M, Coleman E, Slavin S, Walsh KB, Star M, Flaherty ML, Martini SR, Kissela B, Kleindorfer D. Becker CJ, et al. Among authors: flaherty ml. Neurology. 2024 Jun 11;102(11):e209423. doi: 10.1212/WNL.0000000000209423. Epub 2024 May 17. Neurology. 2024. PMID: 38759136
499 results