Flaherty DP - Search Results

1

Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA.

Colquhoun JM, Ha L, Beckley A, Meyers B, Flaherty DP, Dunman PM. Colquhoun JM, et al. Among authors: flaherty dp. Antibiotics (Basel). 2019 Apr 28;8(2):48. doi: 10.3390/antibiotics8020048. Antibiotics (Basel). 2019. PMID: 31035380 Free PMC article.

2

Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.

Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. Perlmutter JI, et al. Among authors: flaherty dp. J Med Chem. 2014 Oct 23;57(20):8540-62. doi: 10.1021/jm5010682. Epub 2014 Oct 6. J Med Chem. 2014. PMID: 25238555 Free PMC article.

3

Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.

Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP. Ha L, et al. Among authors: flaherty dp. Acta Crystallogr F Struct Biol Commun. 2018 Oct 1;74(Pt 10):632-637. doi: 10.1107/S2053230X18011512. Epub 2018 Sep 19. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 30279314 Free PMC article.

4

Optimization of 4-Substituted Benzenesulfonamide Scaffold To Reverse Acinetobacter baumannii Serum-Adaptive Efflux Associated Antibiotic Tolerance.

Chojnacki M, Cao X, Young M, Fritz RN, Dunman PM, Flaherty DP. Chojnacki M, et al. Among authors: flaherty dp. ChemMedChem. 2020 Sep 16;15(18):1731-1740. doi: 10.1002/cmdc.202000328. Epub 2020 Aug 13. ChemMedChem. 2020. PMID: 32681604 Free PMC article.

5

Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA.

Chojnacki M, Cao X, Flaherty DP, Dunman PM. Chojnacki M, et al. Among authors: flaherty dp. Antibiotics (Basel). 2021 Mar 31;10(4):369. doi: 10.3390/antibiotics10040369. Antibiotics (Basel). 2021. PMID: 33807357 Free PMC article.

6

Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance.

Young M, Chojnacki M, Blanchard C, Cao X, Johnson WL, Flaherty D, Dunman PM. Young M, et al. Antibiotics (Basel). 2023 Jul 11;12(7):1173. doi: 10.3390/antibiotics12071173. Antibiotics (Basel). 2023. PMID: 37508269 Free PMC article.

7

Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.

Krabill AD, Chen H, Hussain S, Hewitt CS, Imhoff RD, Muli CS, Das C, Galardy PJ, Wendt MK, Flaherty DP. Krabill AD, et al. Among authors: flaherty dp. Molecules. 2021 Feb 25;26(5):1227. doi: 10.3390/molecules26051227. Molecules. 2021. PMID: 33668938 Free PMC article.

8

Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae.

Hewitt CS, Abutaleb NS, Elhassanny AEM, Nocentini A, Cao X, Amos DP, Youse MS, Holly KJ, Marapaka AK, An W, Kaur J, Krabill AD, Elkashif A, Elgammal Y, Graboski AL, Supuran CT, Seleem MN, Flaherty DP. Hewitt CS, et al. Among authors: flaherty dp. ACS Infect Dis. 2021 Jul 9;7(7):1969-1984. doi: 10.1021/acsinfecdis.1c00055. Epub 2021 Mar 25. ACS Infect Dis. 2021. PMID: 33765392 Free PMC article.

9

Discovery and validation of a novel inhibitor of HYPE-mediated AMPylation.

Camara A, Chugh H, George A, Dolidze L, Ryu K, Holly KJ, Flaherty DP, Mattoo S. Camara A, et al. Among authors: flaherty dp. Cell Stress Chaperones. 2024 Apr 9;29(3):404-424. doi: 10.1016/j.cstres.2024.04.001. Online ahead of print. Cell Stress Chaperones. 2024. PMID: 38599565 Free PMC article.

10

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca²⁺/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.

Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP. Kaur J, et al. Among authors: flaherty dp. Eur J Med Chem. 2019 Jan 15;162:568-585. doi: 10.1016/j.ejmech.2018.11.036. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30472604 Free PMC article.

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