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Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.
Armani E, Capaldi C, Bagnacani V, Saccani F, Aquino G, Puccini P, Facchinetti F, Martucci C, Moretto N, Villetti G, Patacchini R, Civelli M, Hurley C, Jennings A, Alcaraz L, Bloomfield D, Briggs M, Daly S, Panchal T, Russell V, Wicks S, Finch H, Fitzgerald M, Fox C, Delcanale M. Armani E, et al. Among authors: fitzgerald m. J Med Chem. 2022 May 26;65(10):7170-7192. doi: 10.1021/acs.jmedchem.2c00115. Epub 2022 May 11. J Med Chem. 2022. PMID: 35546685
p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation.
Medicherla S, Fitzgerald MF, Spicer D, Woodman P, Ma JY, Kapoun AM, Chakravarty S, Dugar S, Protter AA, Higgins LS. Medicherla S, et al. Among authors: fitzgerald mf. J Pharmacol Exp Ther. 2008 Mar;324(3):921-9. doi: 10.1124/jpet.107.127092. Epub 2007 Dec 4. J Pharmacol Exp Ther. 2008. PMID: 18056868
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
von Nussbaum F, Li VM, Allerheiligen S, Anlauf S, Bärfacker L, Bechem M, Delbeck M, Fitzgerald MF, Gerisch M, Gielen-Haertwig H, Haning H, Karthaus D, Lang D, Lustig K, Meibom D, Mittendorf J, Rosentreter U, Schäfer M, Schäfer S, Schamberger J, Telan LA, Tersteegen A. von Nussbaum F, et al. Among authors: fitzgerald mf. ChemMedChem. 2015 Jul;10(7):1163-73. doi: 10.1002/cmdc.201500131. Epub 2015 Jun 17. ChemMedChem. 2015. PMID: 26083237 Free PMC article.
Acute colonic pseudo-obstruction in polytrauma patients.
Johnny CS, Schlegel RN, Balachandran M, Casey L, Mathew J, Carne P, Varma D, Ban EJ, Fitzgerald MC. Johnny CS, et al. Among authors: fitzgerald mc. J Trauma Acute Care Surg. 2024 May 21. doi: 10.1097/TA.0000000000004392. Online ahead of print. J Trauma Acute Care Surg. 2024. PMID: 38769618
Identification of Selective Imidazopyridine CSF1R Inhibitors.
Kane JL Jr, Asmussen G, Batchelor J, Cromwell M, Fezoui M, Fitzgerald M, Giese B, Gladysheva T, Holley S, Keefe K, Kothe M, Lam B, Lim S, Liu J, Ma L, Metz M, Scholte AA, Shum P, Wei L, Woodworth L, Edling A. Kane JL Jr, et al. Among authors: fitzgerald m. ACS Med Chem Lett. 2024 Apr 30;15(5):722-730. doi: 10.1021/acsmedchemlett.4c00110. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746878
2,858 results