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Page 1
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).
Xu ZB, Chaudhary D, Olland S, Wolfrom S, Czerwinski R, Malakian K, Lin L, Stahl ML, Joseph-McCarthy D, Benander C, Fitz L, Greco R, Somers WS, Mosyak L. Xu ZB, et al. Among authors: fitz l. J Biol Chem. 2004 Nov 26;279(48):50401-9. doi: 10.1074/jbc.M409216200. Epub 2004 Sep 13. J Biol Chem. 2004. PMID: 15364937 Free article.
Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
Cole DC, Asselin M, Brennan A, Czerwinski R, Ellingboe JW, Fitz L, Greco R, Huang X, Joseph-McCarthy D, Kelly MF, Kirisits M, Lee J, Li Y, Morgan P, Stock JR, Tsao DH, Wissner A, Yang X, Chaudhary D. Cole DC, et al. Among authors: fitz l. J Med Chem. 2008 Oct 9;51(19):5958-63. doi: 10.1021/jm800214a. Epub 2008 Sep 11. J Med Chem. 2008. PMID: 18783200
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Olland AM, Strand J, Presman E, Czerwinski R, Joseph-McCarthy D, Krykbaev R, Schlingmann G, Chopra R, Lin L, Fleming M, Kriz R, Stahl M, Somers W, Fitz L, Mosyak L. Olland AM, et al. Among authors: fitz l. Protein Sci. 2009 Mar;18(3):569-78. doi: 10.1002/pro.63. Protein Sci. 2009. PMID: 19241384 Free PMC article.
Identification and characterization of acidic mammalian chitinase inhibitors.
Cole DC, Olland AM, Jacob J, Brooks J, Bursavich MG, Czerwinski R, DeClercq C, Johnson M, Joseph-McCarthy D, Ellingboe JW, Lin L, Nowak P, Presman E, Strand J, Tam A, Williams CM, Yao S, Tsao DH, Fitz LJ. Cole DC, et al. Among authors: fitz lj. J Med Chem. 2010 Aug 26;53(16):6122-8. doi: 10.1021/jm100533p. J Med Chem. 2010. PMID: 20666458
Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions.
Zhong X, Kieras E, Sousa E, D'Antona A, Baber JC, He T, Desharnais J, Wood L, Luxenberg D, Stahl M, Kriz R, Lin L, Somers W, Fitz LJ, Wright JF. Zhong X, et al. Among authors: fitz lj. J Biol Chem. 2013 Jan 11;288(2):1409-19. doi: 10.1074/jbc.M112.417717. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184956 Free PMC article.
Kinetic characterization of recombinant human acidic mammalian chitinase.
Chou YT, Yao S, Czerwinski R, Fleming M, Krykbaev R, Xuan D, Zhou H, Brooks J, Fitz L, Strand J, Presman E, Lin L, Aulabaugh A, Huang X. Chou YT, et al. Among authors: fitz l. Biochemistry. 2006 Apr 11;45(14):4444-54. doi: 10.1021/bi0525977. Biochemistry. 2006. PMID: 16584180
Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys.
Kasaian MT, Tan XY, Jin M, Fitz L, Marquette K, Wood N, Cook TA, Lee J, Widom A, Agostinelli R, Bree A, Schlerman FJ, Olland S, Wadanoli M, Sypek J, Gill D, Goldman SJ, Tchistiakova L. Kasaian MT, et al. Among authors: fitz l. J Pharmacol Exp Ther. 2008 Jun;325(3):882-92. doi: 10.1124/jpet.108.136515. Epub 2008 Mar 12. J Pharmacol Exp Ther. 2008. PMID: 18337474
Characterization of murine Flt4 ligand/VEGF-C.
Fitz LJ, Morris JC, Towler P, Long A, Burgess P, Greco R, Wang J, Gassaway R, Nickbarg E, Kovacic S, Ciarletta A, Giannotti J, Finnerty H, Zollner R, Beier DR, Leak LV, Turner KJ, Wood CR. Fitz LJ, et al. Oncogene. 1997 Jul 31;15(5):613-8. doi: 10.1038/sj.onc.1201191. Oncogene. 1997. PMID: 9247316
45 results