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Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial.
Silverman MH, Strand V, Markovits D, Nahir M, Reitblat T, Molad Y, Rosner I, Rozenbaum M, Mader R, Adawi M, Caspi D, Tishler M, Langevitz P, Rubinow A, Friedman J, Green L, Tanay A, Ochaion A, Cohen S, Kerns WD, Cohn I, Fishman-Furman S, Farbstein M, Yehuda SB, Fishman P. Silverman MH, et al. Among authors: fishman p, fishman furman s. J Rheumatol. 2008 Jan;35(1):41-8. Epub 2007 Nov 15. J Rheumatol. 2008. PMID: 18050382 Clinical Trial.
The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
Ochaion A, Bar-Yehuda S, Cohen S, Amital H, Jacobson KA, Joshi BV, Gao ZG, Barer F, Patoka R, Del Valle L, Perez-Liz G, Fishman P. Ochaion A, et al. Among authors: fishman p. Biochem Pharmacol. 2008 Aug 15;76(4):482-94. doi: 10.1016/j.bcp.2008.05.032. Epub 2008 Jun 17. Biochem Pharmacol. 2008. PMID: 18602896 Free PMC article.
Adenosine receptors and cancer.
Fishman P, Bar-Yehuda S, Synowitz M, Powell JD, Klotz KN, Gessi S, Borea PA. Fishman P, et al. Handb Exp Pharmacol. 2009;(193):399-441. doi: 10.1007/978-3-540-89615-9_14. Handb Exp Pharmacol. 2009. PMID: 19639290 Free PMC article. Review.
651 results