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High-level semi-synthetic production of the potent antimalarial artemisinin.
Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. Paddon CJ, et al. Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10. Nature. 2013. PMID: 23575629
Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target.
Hunerdosse DM, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh JR, Zhong S, Nomura DK. Hunerdosse DM, et al. Among authors: fisher kj. ACS Chem Biol. 2014 Dec 19;9(12):2905-13. doi: 10.1021/cb500717g. Epub 2014 Nov 5. ACS Chem Biol. 2014. PMID: 25343321 Free PMC article.
Kilo-Scale GMP Synthesis of Renewable Semisynthetic Vaccine-Grade Squalene.
Fisher KJ, Shirtcliff L, Buchanan G, Thompson AW, Woolard FX, LaMunyon DH, Marshall JL, Baranouskas MB, Voelker RB, Lusk JS, Wells CE, Mohamath R, Kinsey R, Lykins WR, Ramer-Denisoff G, Fox CB, Paddon CJ, McPhee D. Fisher KJ, et al. Org Process Res Dev. 2023 Dec 15;27(12):2317-2328. doi: 10.1021/acs.oprd.3c00300. Epub 2023 Nov 16. Org Process Res Dev. 2023. PMID: 38524776
129 results