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Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Mehel H, et al. Among authors: fischmeister r. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. J Am Coll Cardiol. 2013. PMID: 23810893 Free article.
cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.
Rivet-Bastide M, Vandecasteele G, Hatem S, Verde I, Bénardeau A, Mercadier JJ, Fischmeister R. Rivet-Bastide M, et al. Among authors: fischmeister r. J Clin Invest. 1997 Jun 1;99(11):2710-8. doi: 10.1172/JCI119460. J Clin Invest. 1997. PMID: 9169501 Free PMC article.
Recently, EHNA was shown to block the activity of purified soluble cGMPstimulated phosphodiesterase (PDE2) from frog, human, and porcine heart with an apparent Ki value of approximately 1 microM and with negligible effects on Ca2+/calmodulin PDE (PDE1), cGMP-inhibited PDE (PDE3), …
Recently, EHNA was shown to block the activity of purified soluble cGMPstimulated phosphodiesterase (PDE2) from frog, human, and porcine hea …
Methylene blue is a muscarinic antagonist in cardiac myocytes.
Abi-Gerges N, Eschenhagen T, Hove-Madsen L, Fischmeister R, Mery PF. Abi-Gerges N, et al. Among authors: fischmeister r. Mol Pharmacol. 1997 Sep;52(3):482-90. doi: 10.1124/mol.52.3.482. Mol Pharmacol. 1997. PMID: 9281611
178 results