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DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages.
Subudhi AK, Green JL, Satyam R, Salunke RP, Lenz T, Shuaib M, Isaioglou I, Abel S, Gupta M, Esau L, Mourier T, Nugmanova R, Mfarrej S, Shivapurkar R, Stead Z, Rached FB, Ostwal Y, Sougrat R, Dada A, Kadamany AF, Fischle W, Merzaban J, Knuepfer E, Ferguson DJP, Gupta I, Le Roch KG, Holder AA, Pain A. Subudhi AK, et al. Among authors: fischle w. Nat Microbiol. 2023 Nov;8(11):2154-2169. doi: 10.1038/s41564-023-01497-6. Epub 2023 Oct 26. Nat Microbiol. 2023. PMID: 37884813 Free PMC article.
Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks.
Yuan B, Bi C, Tian Y, Wang J, Jin Y, Alsayegh K, Tehseen M, Yi G, Zhou X, Shao Y, Romero FV, Fischle W, Izpisua Belmonte JC, Hamdan S, Huang Y, Li M. Yuan B, et al. Among authors: fischle w. BMC Biol. 2024 Apr 29;22(1):101. doi: 10.1186/s12915-024-01896-z. BMC Biol. 2024. PMID: 38685010 Free PMC article.
Multimodal interactions drive chromatin phase separation and compaction.
Ukmar-Godec T, Cima-Omori MS, Yerkesh Z, Eswara K, Yu T, Ramesh R, Riviere G, Ibanez de Opakua A, Fischle W, Zweckstetter M. Ukmar-Godec T, et al. Among authors: fischle w. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2308858120. doi: 10.1073/pnas.2308858120. Epub 2023 Dec 4. Proc Natl Acad Sci U S A. 2023. PMID: 38048471 Free PMC article.
PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages.
Subudhi AK, Green JL, Satyam R, Lenz T, Salunke RP, Shuaib M, Isaioglou I, Abel S, Gupta M, Esau L, Mourier T, Nugmanova R, Mfarrej S, Sivapurkar R, Stead Z, Rached FB, Otswal Y, Sougrat R, Dada A, Kadamany AF, Fischle W, Merzaban J, Knuepfer E, Ferguson DJP, Gupta I, Le Roch KG, Holder AA, Pain A. Subudhi AK, et al. Among authors: fischle w. bioRxiv [Preprint]. 2023 May 24:2023.05.23.541898. doi: 10.1101/2023.05.23.541898. bioRxiv. 2023. PMID: 37293082 Free PMC article. Updated. Preprint.
Spys Make Asymmetric Chromatin.
Eswara K, Fischle W. Eswara K, et al. Among authors: fischle w. ACS Cent Sci. 2022 Feb 23;8(2):146-149. doi: 10.1021/acscentsci.2c00086. Epub 2022 Feb 3. ACS Cent Sci. 2022. PMID: 35233445 Free PMC article. No abstract available.
Unconventional metabolites in chromatin regulation.
Gapa L, Alfardus H, Fischle W. Gapa L, et al. Among authors: fischle w. Biosci Rep. 2022 Jan 28;42(1):BSR20211558. doi: 10.1042/BSR20211558. Biosci Rep. 2022. PMID: 34988581 Free PMC article.
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis.
Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko Ł, Li W, Mazur PK, Gozani O. Sengupta D, et al. Among authors: fischle w. Mol Cell. 2021 Nov 4;81(21):4481-4492.e9. doi: 10.1016/j.molcel.2021.08.034. Epub 2021 Sep 22. Mol Cell. 2021. PMID: 34555356 Free PMC article.
99 results