Fischer H - Search Results

1

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.

Di L, Artursson P, Avdeef A, Ecker GF, Faller B, Fischer H, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, Sugano K. Di L, et al. Among authors: fischer h. Drug Discov Today. 2012 Aug;17(15-16):905-12. doi: 10.1016/j.drudis.2012.03.015. Epub 2012 Apr 4. Drug Discov Today. 2012. PMID: 22507594 Review.

2

Coexistence of passive and carrier-mediated processes in drug transport.

Sugano K, Kansy M, Artursson P, Avdeef A, Bendels S, Di L, Ecker GF, Faller B, Fischer H, Gerebtzoff G, Lennernaes H, Senner F. Sugano K, et al. Among authors: fischer h. Nat Rev Drug Discov. 2010 Aug;9(8):597-614. doi: 10.1038/nrd3187. Nat Rev Drug Discov. 2010. PMID: 20671764 Review.

3

Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists.

Kansy M, Avdeef A, Fischer H. Kansy M, et al. Among authors: fischer h. Drug Discov Today Technol. 2004 Dec;1(4):349-55. doi: 10.1016/j.ddtec.2004.11.013. Drug Discov Today Technol. 2004. PMID: 24981614

4

Can we discover pharmacological promiscuity early in the drug discovery process?

Peters JU, Hert J, Bissantz C, Hillebrecht A, Gerebtzoff G, Bendels S, Tillier F, Migeon J, Fischer H, Guba W, Kansy M. Peters JU, et al. Among authors: fischer h. Drug Discov Today. 2012 Apr;17(7-8):325-35. doi: 10.1016/j.drudis.2012.01.001. Epub 2012 Jan 16. Drug Discov Today. 2012. PMID: 22269136 Review.

5

Carrier Mediated Distribution System (CAMDIS): a new approach for the measurement of octanol/water distribution coefficients.

Wagner B, Fischer H, Kansy M, Seelig A, Assmus F. Wagner B, et al. Among authors: fischer h. Eur J Pharm Sci. 2015 Feb 20;68:68-77. doi: 10.1016/j.ejps.2014.12.009. Epub 2014 Dec 13. Eur J Pharm Sci. 2015. PMID: 25513709

6

Permeation of permanently positive charged molecules through artificial membranes--influence of physico-chemical properties.

Fischer H, Kansy M, Avdeef A, Senner F. Fischer H, et al. Eur J Pharm Sci. 2007 May;31(1):32-42. doi: 10.1016/j.ejps.2007.02.001. Epub 2007 Feb 11. Eur J Pharm Sci. 2007. PMID: 17416489

7

A potentiometric titration method for the crystallization of drug-like organic molecules.

Du-Cuny L, Huwyler J, Fischer H, Kansy M. Du-Cuny L, et al. Among authors: fischer h. Int J Pharm. 2007 Sep 5;342(1-2):161-7. doi: 10.1016/j.ijpharm.2007.05.030. Epub 2007 May 21. Int J Pharm. 2007. PMID: 17587517

8

Unbound Brain-to-Plasma Partition Coefficient, K_p,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.

Loryan I, Reichel A, Feng B, Bundgaard C, Shaffer C, Kalvass C, Bednarczyk D, Morrison D, Lesuisse D, Hoppe E, Terstappen GC, Fischer H, Di L, Colclough N, Summerfield S, Buckley ST, Maurer TS, Fridén M. Loryan I, et al. Among authors: fischer h. Pharm Res. 2022 Jul;39(7):1321-1341. doi: 10.1007/s11095-022-03246-6. Epub 2022 Apr 11. Pharm Res. 2022. PMID: 35411506 Free PMC article.

9

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.

Huchet QA, Kuhn B, Wagner B, Kratochwil NA, Fischer H, Kansy M, Zimmerli D, Carreira EM, Müller K. Huchet QA, et al. Among authors: fischer h. J Med Chem. 2015 Nov 25;58(22):9041-60. doi: 10.1021/acs.jmedchem.5b01455. Epub 2015 Nov 17. J Med Chem. 2015. PMID: 26523333

10

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.

Vorberg R, Trapp N, Zimmerli D, Wagner B, Fischer H, Kratochwil NA, Kansy M, Carreira EM, Müller K. Vorberg R, et al. Among authors: fischer h. ChemMedChem. 2016 Oct 6;11(19):2216-2239. doi: 10.1002/cmdc.201600325. Epub 2016 Sep 15. ChemMedChem. 2016. PMID: 27629993

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