Fischer F - Search Results

1

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker CF, Zerweck J, Schutkowski M, Steegborn C. Rauh D, et al. Among authors: fischer f. Nat Commun. 2013;4:2327. doi: 10.1038/ncomms3327. Nat Commun. 2013. PMID: 23995836 Free article.

2

A molecular mechanism for direct sirtuin activation by resveratrol.

Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C. Gertz M, et al. Among authors: fischer f. PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185430 Free PMC article.

3

New assays and approaches for discovery and design of Sirtuin modulators.

Schutkowski M, Fischer F, Roessler C, Steegborn C. Schutkowski M, et al. Among authors: fischer f. Expert Opin Drug Discov. 2014 Feb;9(2):183-99. doi: 10.1517/17460441.2014.875526. Epub 2014 Jan 2. Expert Opin Drug Discov. 2014. PMID: 24382304 Review.

4

Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.

Fischer F, Gertz M, Suenkel B, Lakshminarasimhan M, Schutkowski M, Steegborn C. Fischer F, et al. PLoS One. 2012;7(9):e45098. doi: 10.1371/journal.pone.0045098. Epub 2012 Sep 19. PLoS One. 2012. PMID: 23028781 Free PMC article.

5

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.

Suenkel B, Fischer F, Steegborn C. Suenkel B, et al. Among authors: fischer f. Bioorg Med Chem Lett. 2013 Jan 1;23(1):143-6. doi: 10.1016/j.bmcl.2012.10.136. Epub 2012 Nov 12. Bioorg Med Chem Lett. 2013. PMID: 23195732

6

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.

Gertz M, Fischer F, Nguyen GT, Lakshminarasimhan M, Schutkowski M, Weyand M, Steegborn C. Gertz M, et al. Among authors: fischer f. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. doi: 10.1073/pnas.1303628110. Epub 2013 Jul 9. Proc Natl Acad Sci U S A. 2013. PMID: 23840057 Free PMC article.

7

Proteinase K improves quantitative acylation studies.

Fränzel B, Fischer F, Steegborn C, Wolters DA. Fränzel B, et al. Among authors: fischer f. Proteomics. 2015 Jan;15(1):44-7. doi: 10.1002/pmic.201400015. Epub 2014 Dec 11. Proteomics. 2015. PMID: 25332194

8

Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.

Gertz M, Fischer F, Leipelt M, Wolters D, Steegborn C. Gertz M, et al. Among authors: fischer f. Aging (Albany NY). 2009 Jan 30;1(2):254-65. doi: 10.18632/aging.100017. Aging (Albany NY). 2009. PMID: 20157513 Free PMC article.

9

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.

Gertz M, Fischer F, Wolters D, Steegborn C. Gertz M, et al. Among authors: fischer f. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5705-9. doi: 10.1073/pnas.0800691105. Epub 2008 Apr 14. Proc Natl Acad Sci U S A. 2008. PMID: 18413607 Free PMC article.

10

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.

Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. Laurent G, et al. Among authors: fischer f. Mol Cell. 2013 Jun 6;50(5):686-98. doi: 10.1016/j.molcel.2013.05.012. Mol Cell. 2013. PMID: 23746352 Free PMC article.

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