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Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein.
Romero MJ, Yue Q, Singla B, Hamacher J, Sridhar S, Moseley AS, Song C, Mraheil MA, Fischer B, Zeitlinger M, Chakraborty T, Fulton D, Gan L, Annex BH, Csanyi G, Eaton DC, Lucas R. Romero MJ, et al. Among authors: fischer b. Front Immunol. 2023 Aug 10;14:1241448. doi: 10.3389/fimmu.2023.1241448. eCollection 2023. Front Immunol. 2023. PMID: 37638055 Free PMC article.
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. Czikora I, et al. Among authors: fischer b. Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32. doi: 10.1164/rccm.201405-0833OC. Am J Respir Crit Care Med. 2014. PMID: 25029038 Free PMC article.
The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition.
Xiong C, Yang G, Kumar S, Aggarwal S, Leustik M, Snead C, Hamacher J, Fischer B, Umapathy NS, Hossain H, Wendel A, Catravas JD, Verin AD, Fulton D, Black SM, Chakraborty T, Lucas R. Xiong C, et al. Among authors: fischer b. Vascul Pharmacol. 2010 May-Jun;52(5-6):207-13. doi: 10.1016/j.vph.2009.12.010. Epub 2010 Jan 13. Vascul Pharmacol. 2010. PMID: 20074664 Free PMC article.
Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.
Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T. Lucas R, et al. Among authors: fischer b. Am J Respir Cell Mol Biol. 2012 Oct;47(4):445-53. doi: 10.1165/rcmb.2011-0332OC. Epub 2012 May 10. Am J Respir Cell Mol Biol. 2012. PMID: 22582175 Free PMC article.
The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.
Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I. Lucas R, et al. Among authors: fischer b. J Biol Chem. 2016 Nov 4;291(45):23440-23451. doi: 10.1074/jbc.M116.718163. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645999 Free PMC article.
Potent anti-inflammatory activity of the lectin-like domain of TNF in joints.
Pinto ACMD, Nunes RM, Nogueira IA, Fischer B, Lucas R, Girão-Carmona VCC, de Oliveira VLS, Amaral FA, Schett G, Rocha FAC. Pinto ACMD, et al. Among authors: fischer b. Front Immunol. 2022 Oct 31;13:1049368. doi: 10.3389/fimmu.2022.1049368. eCollection 2022. Front Immunol. 2022. PMID: 36389831 Free PMC article.
TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B.
Willam A, Aufy M, Tzotzos S, El-Malazi D, Poser F, Wagner A, Unterköfler B, Gurmani D, Martan D, Iqbal SM, Fischer B, Fischer H, Pietschmann H, Czikora I, Lucas R, Lemmens-Gruber R, Shabbir W. Willam A, et al. Among authors: fischer b, fischer h. Front Immunol. 2017 May 29;8:601. doi: 10.3389/fimmu.2017.00601. eCollection 2017. Front Immunol. 2017. PMID: 28611771 Free PMC article.
Conformational ensemble of the TNF-derived peptide solnatide in solution.
Martin-Malpartida P, Arrastia-Casado S, Farrera-Sinfreu J, Lucas R, Fischer H, Fischer B, Eaton DC, Tzotzos S, Macias MJ. Martin-Malpartida P, et al. Among authors: fischer b, fischer h. Comput Struct Biotechnol J. 2022 Apr 27;20:2082-2090. doi: 10.1016/j.csbj.2022.04.031. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35601958 Free PMC article.
2,076 results