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Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection.
Fiorucci S, Di Lorenzo A, Renga B, Farneti S, Morelli A, Cirino G. Fiorucci S, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1264-71. doi: 10.1124/jpet.104.072843. Epub 2004 Aug 5. J Pharmacol Exp Ther. 2004. PMID: 15297470
A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis.
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R. Fiorucci S, et al. J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. doi: 10.1124/jpet.105.084905. Epub 2005 Apr 28. J Pharmacol Exp Ther. 2005. PMID: 15860571
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