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Rare genetic variation in VE-PTP is associated with central serous chorioretinopathy, venous dysfunction and glaucoma.
Rämö JT, Gorman B, Weng LC, Jurgens SJ, Singhanetr P, Tieger MG, van Dijk EH, Halladay CW, Wang X, Brinks J, Choi SH, Luo Y; FinnGen, Program VA Million Veteran; Pyarajan S, Nealon CL, Gorin MB, Wu WC, Sobrin L, Kaarniranta K, Yzer S, Palotie A, Peachey NS, Turunen JA, Boon CJ, Ellinor PT, Iyengar SK, Daly MJ, Rossin EJ. Rämö JT, et al. medRxiv [Preprint]. 2024 May 9:2024.05.08.24307013. doi: 10.1101/2024.05.08.24307013. medRxiv. 2024. PMID: 38766240 Free PMC article. Preprint.
To identify potential mechanisms, we analyzed genotype data from 1,477 CSC patients and 455,449 controls in FinnGen. We identified an association for a low-frequency (AF=0.5%) missense variant (rs113791087) in the gene encoding vascular endothelial protein tyrosine phospha …
To identify potential mechanisms, we analyzed genotype data from 1,477 CSC patients and 455,449 controls in FinnGen. We identified an …
GENETIC STUDY OF PSORIASIS HIGHLIGHTS ITS CLOSE LINK WITH SOCIO-ECONOMIC STATUS AND AFFECTIVE SYMPTOMS.
Heikkilä A, Sliz E, Huilaja L; FinnGen; Estonian Biobank Research Team; Reis K, Palta P, Elnahas AG, Reigo A, Esko T, Laisk T, Teder-Laving M, Tasanen K, Kettunen J. Heikkilä A, et al. J Invest Dermatol. 2024 May 17:S0022-202X(24)00358-0. doi: 10.1016/j.jid.2024.03.043. Online ahead of print. J Invest Dermatol. 2024. PMID: 38763176 Free article.
To further improve the understanding of the genetic risk factors impacting the disease, we conducted a discovery GWAS in FinnGen and a subsequent replication and meta-analysis with data from the Estonian Biobank and the UK biobank; the study sample included 925 649 individ …
To further improve the understanding of the genetic risk factors impacting the disease, we conducted a discovery GWAS in FinnGen and …
Potential drug targets for tumors identified through Mendelian randomization analysis.
Song N, Shi P, Cui K, Zeng L, Wang Z, Di W, Li J, Fan Y, Li Z, Zhang J, Su W, Wang H. Song N, et al. Sci Rep. 2024 May 18;14(1):11370. doi: 10.1038/s41598-024-62178-w. Sci Rep. 2024. PMID: 38762700 Free PMC article.
Therefore, we evaluated the human proteins for their causal relationship to for cancer risk and therefore also their potential as drug targets. We used summary tumors data from the FinnGen and cis protein quantitative trait loci (cis-pQTL) data from a genome-wide associati …
Therefore, we evaluated the human proteins for their causal relationship to for cancer risk and therefore also their potential as drug targe …
Association between allergic diseases and both psoriasis and psoriatic arthritis: a bidirectional 2-sample Mendelian randomization study.
Zhao D, Wu S, Wang Y, Zheng H, Zhu M. Zhao D, et al. Arch Dermatol Res. 2024 May 18;316(5):181. doi: 10.1007/s00403-024-02978-2. Arch Dermatol Res. 2024. PMID: 38762688
The summary statistics for PSO (9267 cases and 360,471 controls) and PSA (3186 cases and 240,862 controls) were sourced from the FinnGen database. The primary analytical approach employed inverse variance weighting (IVW) as the main method within TSMR. ...
The summary statistics for PSO (9267 cases and 360,471 controls) and PSA (3186 cases and 240,862 controls) were sourced from the FinnGen …
Causal association of sleep traits with the risk of thyroid cancer: A mendelian randomization study.
Zong L, Liu G, He H, Huang D. Zong L, et al. BMC Cancer. 2024 May 17;24(1):605. doi: 10.1186/s12885-024-12376-6. BMC Cancer. 2024. PMID: 38760772 Free PMC article.
METHOD: Summary single nucleotide polymorphism (SNP)-phenotype association data were obtained from published genome-wide association studies (GWASs) using the FinnGen and UK Biobank databases. A series of screening processes were performed to select qualified SNPs strongly …
METHOD: Summary single nucleotide polymorphism (SNP)-phenotype association data were obtained from published genome-wide association studies …
Genetic Association between Lipid-Regulating Drug Targets and Diabetic Retinopathy: A Drug Target Mendelian Randomization Study.
Chen S, Zhang M, Yang P, Guo J, Liu L, Yang Z, Nan K. Chen S, et al. J Lipids. 2024 May 9;2024:5324127. doi: 10.1155/2024/5324127. eCollection 2024. J Lipids. 2024. PMID: 38757060 Free PMC article.
The exposure data were obtained from the IEU OpenGWAS project. The outcome dataset related to DR was obtained from the FinnGen research project. Inverse-variance-weighted MR (IVW-MR) was used to calculate the effect estimates by each target. ...
The exposure data were obtained from the IEU OpenGWAS project. The outcome dataset related to DR was obtained from the FinnGen resear …
Causal relationships between blood metabolites and diabetic retinopathy: a two-sample Mendelian randomization study.
Yang C, Ma Y, Yao M, Jiang Q, Xue J. Yang C, et al. Front Endocrinol (Lausanne). 2024 May 1;15:1383035. doi: 10.3389/fendo.2024.1383035. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38752182 Free PMC article.
The genetic variables for exposure were obtained from the genome-wide association study (GWAS) dataset of 486 blood metabolites, while the genetic predictors for outcomes including all-stage DR (All DR), non-proliferative DR (NPDR) and proliferative DR (PDR) were derived from the …
The genetic variables for exposure were obtained from the genome-wide association study (GWAS) dataset of 486 blood metabolites, while the g …
The causal relationship between COVID-19 and ten esophageal diseases: a study utilizing Mendelian randomization.
He X, Li Y, Liu J, Yan G, Gao X, Li G, Wei L, Feng G, Li J, Zhou H. He X, et al. Front Med (Lausanne). 2024 May 1;11:1346888. doi: 10.3389/fmed.2024.1346888. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38751976 Free PMC article.
Additionally, summary statistics for ten esophageal diseases as outcomes were sourced from the GWAS Catalog and FinnGen databases. Univariate Mendelian randomization (MR) analysis was utilized to thoroughly investigate and validate the potential causal association between …
Additionally, summary statistics for ten esophageal diseases as outcomes were sourced from the GWAS Catalog and FinnGen databases. Un …
Genetic Evidence for a Causal Relationship Between Innate Leukocytes and the Risk of Digestive System Cancers in East Asians and Europeans.
Zhu JH, Xu BJ, Pang XY, Lian J, Gu K, Ji SJ, Lu HB. Zhu JH, et al. World J Oncol. 2024 Jun;15(3):482-491. doi: 10.14740/wjon1860. Epub 2024 May 7. World J Oncol. 2024. PMID: 38751703 Free PMC article.
Summary-level data for the cancers were obtained from Biobank Japan (212,978 individuals) and the FinnGen consortium (178,802 participants). Univariable and multivariable Mendelian randomization (MR) analyses were performed on East Asians and Europeans separately. ...
Summary-level data for the cancers were obtained from Biobank Japan (212,978 individuals) and the FinnGen consortium (178,802 partici …
Thyroid Function Impact on Cardiac Structure, Function and Disease Risk: Evidence of Causal Associations in European Ancestry.
Ruan W, Zhou X, Li J, Wang T, Liu H, Zhang G, Lin K. Ruan W, et al. Heart Rhythm. 2024 May 13:S1547-5271(24)02563-3. doi: 10.1016/j.hrthm.2024.05.021. Online ahead of print. Heart Rhythm. 2024. PMID: 38750912
These findings were further corroborated in the independent FinnGen cohort. However, no clear evidence was found for relationships between thyroid function and other cardiovascular outcomes and cardiac structure and function. ...
These findings were further corroborated in the independent FinnGen cohort. However, no clear evidence was found for relationships be …
1,065 results