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Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis.
Peixoto JF, Gonçalves-Oliveira LF, Souza-Silva F, de Castro Côrtes LM, Finkelstein LC, Dias-Lopes G, Patricio BFC, Lima CGS, Rocha HVA, da Silva FC, Ferreira VF, Pereira BAS, Alves CR. Peixoto JF, et al. Among authors: finkelstein lc. Int J Parasitol Drugs Drug Resist. 2024 Apr;24:100525. doi: 10.1016/j.ijpddr.2024.100525. Epub 2024 Feb 9. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38359731 Free PMC article.
Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite.
Souza-Silva F, Bourguignon SC, Pereira BA, Côrtes LM, de Oliveira LF, Henriques-Pons A, Finkelstein LC, Ferreira VF, Carneiro PF, de Pinho RT, Caffarena ER, Alves CR. Souza-Silva F, et al. Among authors: finkelstein lc. Antimicrob Agents Chemother. 2015 Apr;59(4):1910-8. doi: 10.1128/AAC.04742-14. Epub 2015 Jan 12. Antimicrob Agents Chemother. 2015. PMID: 25583728 Free PMC article.
Increasing in cysteine proteinase B expression and enzymatic activity during in vitro differentiation of Leishmania (Viannia) braziliensis: First evidence of modulation during morphological transition.
Gomes CB, -Silva FS, Charret KD, Pereira BA, Finkelstein LC, Santos-de-Souza R, de Castro Côrtes LM, Pereira MC, Rodrigues de Oliveira FO Jr, Alves CR. Gomes CB, et al. Among authors: finkelstein lc. Biochimie. 2017 Feb;133:28-36. doi: 10.1016/j.biochi.2016.11.015. Epub 2016 Dec 3. Biochimie. 2017. PMID: 27919786
Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis.
Rebello KM, Côrtes LM, Pereira BA, Pascarelli BM, Côrte-Real S, Finkelstein LC, Pinho RT, d'Avila-Levy CM, Alves CR. Rebello KM, et al. Among authors: finkelstein lc. Parasitol Res. 2009 Dec;106(1):95-104. doi: 10.1007/s00436-009-1632-5. Epub 2009 Sep 24. Parasitol Res. 2009. PMID: 19777260