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A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.
Fingerle-Rowson G, Kaleswarapu DR, Schlander C, Kabgani N, Brocks T, Reinart N, Busch R, Schütz A, Lue H, Du X, Liu A, Xiong H, Chen Y, Nemajerova A, Hallek M, Bernhagen J, Leng L, Bucala R. Fingerle-Rowson G, et al. Mol Cell Biol. 2009 Apr;29(7):1922-32. doi: 10.1128/MCB.01907-08. Epub 2009 Feb 2. Mol Cell Biol. 2009. PMID: 19188446 Free PMC article.
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.
Verschuren L, Kooistra T, Bernhagen J, Voshol PJ, Ouwens DM, van Erk M, de Vries-van der Weij J, Leng L, van Bockel JH, van Dijk KW, Fingerle-Rowson G, Bucala R, Kleemann R. Verschuren L, et al. Circ Res. 2009 Jul 2;105(1):99-107. doi: 10.1161/CIRCRESAHA.109.199166. Epub 2009 May 28. Circ Res. 2009. PMID: 19478200 Free PMC article.
Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation.
Gao XM, Liu Y, White D, Su Y, Drew BG, Bruce CR, Kiriazis H, Xu Q, Jennings N, Bobik A, Febbraio MA, Kingwell BA, Bucala R, Fingerle-Rowson G, Dart AM, Morand EF, Du XJ. Gao XM, et al. J Mol Cell Cardiol. 2011 Jun;50(6):991-9. doi: 10.1016/j.yjmcc.2010.12.022. Epub 2011 Jan 6. J Mol Cell Cardiol. 2011. PMID: 21215754
89 results