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Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition.
Zhang J, Pearson AJ, Sabherwal N, Telfer BA, Ali N, Kan K, Xu Q, Zhang W, Chen F, Li S, Wang J, Gray NS, Risa-Ebrí B, Finegan KG, Cross MJ, Giurisato E, Whitmarsh AJ, Tournier C. Zhang J, et al. Among authors: finegan kg. Cancer Res Commun. 2022 Mar 10;2(3):131-145. doi: 10.1158/2767-9764.CRC-21-0089. Cancer Res Commun. 2022. PMID: 36466034 Free PMC article.
SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules.
Elhemely MA, Belgath AA, El-Sayed S, Burusco KK, Kadirvel M, Tirella A, Finegan K, Bryce RA, Stratford IJ, Freeman S. Elhemely MA, et al. Among authors: finegan k. J Med Chem. 2022 Mar 24;65(6):4783-4797. doi: 10.1021/acs.jmedchem.1c01936. Epub 2022 Mar 15. J Med Chem. 2022. PMID: 35290041 Free PMC article.
The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion.
Xu Q, Zhang J, Telfer BA, Zhang H, Ali N, Chen F, Risa B, Pearson AJ, Zhang W, Finegan KG, Ucar A, Giurisato E, Tournier C. Xu Q, et al. Among authors: finegan kg. Oncogene. 2021 Jun;40(23):3929-3941. doi: 10.1038/s41388-021-01798-2. Epub 2021 May 12. Oncogene. 2021. PMID: 33981002 Free PMC article.
Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer.
Green D, Eyre H, Singh A, Taylor JT, Chu J, Jeys L, Sumathi V, Coonar A, Rassl D, Babur M, Forster D, Alzabin S, Ponthan F, McMahon A, Bigger B, Reekie T, Kassiou M, Williams K, Dalmay T, Fraser WD, Finegan KG. Green D, et al. Among authors: finegan kg. Oncogene. 2020 Aug;39(33):5553-5569. doi: 10.1038/s41388-020-1379-0. Epub 2020 Jul 13. Oncogene. 2020. PMID: 32655131 Free PMC article.
Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis.
Giurisato E, Lonardi S, Telfer B, Lussoso S, Risa-Ebrí B, Zhang J, Russo I, Wang J, Santucci A, Finegan KG, Gray NS, Vermi W, Tournier C. Giurisato E, et al. Among authors: finegan kg. Cancer Res. 2020 Aug 15;80(16):3319-3330. doi: 10.1158/0008-5472.CAN-19-2416. Epub 2020 Jun 19. Cancer Res. 2020. PMID: 32561530 Free PMC article.
Intra brainstem connectivity is impaired in chronic fatigue syndrome.
Barnden LR, Shan ZY, Staines DR, Marshall-Gradisnik S, Finegan K, Ireland T, Bhuta S. Barnden LR, et al. Among authors: finegan k. Neuroimage Clin. 2019;24:102045. doi: 10.1016/j.nicl.2019.102045. Epub 2019 Oct 19. Neuroimage Clin. 2019. PMID: 31671321 Free PMC article.
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