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PDX1LOW MAFALOW β-cells contribute to islet function and insulin release.
Nasteska D, Fine NHF, Ashford FB, Cuozzo F, Viloria K, Smith G, Dahir A, Dawson PWJ, Lai YC, Bastidas-Ponce A, Bakhti M, Rutter GA, Fiancette R, Nano R, Piemonti L, Lickert H, Zhou Q, Akerman I, Hodson DJ. Nasteska D, et al. Among authors: fine nhf. Nat Commun. 2021 Jan 29;12(1):674. doi: 10.1038/s41467-020-20632-z. Nat Commun. 2021. PMID: 33514698 Free PMC article.
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.
Mehta ZB, Fine N, Pullen TJ, Cane MC, Hu M, Chabosseau P, Meur G, Velayos-Baeza A, Monaco AP, Marselli L, Marchetti P, Rutter GA. Mehta ZB, et al. Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E488-507. doi: 10.1152/ajpendo.00074.2016. Epub 2016 Jun 21. Am J Physiol Endocrinol Metab. 2016. PMID: 27329800 Free PMC article.
Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion.
Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Fine NHF, et al. Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4. Diabetes. 2018. PMID: 29203512 Free PMC article.
Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology.
Podewin T, Ast J, Broichhagen J, Fine NHF, Nasteska D, Leippe P, Gailer M, Buenaventura T, Kanda N, Jones BJ, M'Kadmi C, Baneres JL, Marie J, Tomas A, Trauner D, Hoffmann-Röder A, Hodson DJ. Podewin T, et al. Among authors: fine nhf. ACS Cent Sci. 2018 Feb 28;4(2):166-179. doi: 10.1021/acscentsci.7b00237. Epub 2018 Jan 16. ACS Cent Sci. 2018. PMID: 29532016 Free PMC article.
Optical control of GPR40 signalling in pancreatic β-cells.
Frank JA, Yushchenko DA, Fine NHF, Duca M, Citir M, Broichhagen J, Hodson DJ, Schultz C, Trauner D. Frank JA, et al. Among authors: fine nhf. Chem Sci. 2017 Nov 1;8(11):7604-7610. doi: 10.1039/c7sc01475a. Epub 2017 Aug 30. Chem Sci. 2017. PMID: 29568424 Free PMC article.
Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.
Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NH, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F. Navarro G, et al. JCI Insight. 2018 Jun 21;3(12):e98607. doi: 10.1172/jci.insight.98607. eCollection 2018 Jun 21. JCI Insight. 2018. PMID: 29925687 Free PMC article.
Optical control of L-type Ca2+ channels using a diltiazem photoswitch.
Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D. Fehrentz T, et al. Among authors: fine nhf. Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16. Nat Chem Biol. 2018. PMID: 30013061
Dimerization of the Sodium/Iodide Symporter.
Thompson RJ, Fletcher A, Brookes K, Nieto H, Alshahrani MM, Mueller JW, Fine NHF, Hodson DJ, Boelaert K, Read ML, Smith VE, McCabe CJ. Thompson RJ, et al. Among authors: fine nhf. Thyroid. 2019 Oct;29(10):1485-1498. doi: 10.1089/thy.2019.0034. Epub 2019 Aug 30. Thyroid. 2019. PMID: 31310151 Free PMC article.
Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.
Sayers SR, Beavil RL, Fine NHF, Huang GC, Choudhary P, Pacholarz KJ, Barran PE, Butterworth S, Mills CE, Cruickshank JK, Silvestre MP, Poppitt SD, McGill AT, Lavery GG, Hodson DJ, Caton PW. Sayers SR, et al. Among authors: fine nhf. Diabetologia. 2020 Feb;63(2):313-323. doi: 10.1007/s00125-019-05029-y. Epub 2019 Nov 15. Diabetologia. 2020. PMID: 31732790 Free PMC article.
20 results