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Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.
Klein AB, Nicolaisen TS, Ørtenblad N, Gejl KD, Jensen R, Fritzen AM, Larsen EL, Karstoft K, Poulsen HE, Morville T, Sahl RE, Helge JW, Lund J, Falk S, Lyngbæk M, Ellingsgaard H, Pedersen BK, Lu W, Finan B, Jørgensen SB, Seeley RJ, Kleinert M, Kiens B, Richter EA, Clemmensen C. Klein AB, et al. Among authors: finan b. Nat Commun. 2021 Feb 15;12(1):1041. doi: 10.1038/s41467-021-21309-x. Nat Commun. 2021. PMID: 33589633 Free PMC article.
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Sekar R, Motzler K, Kwon Y, Novikoff A, Jülg J, Najafi B, Wang S, Warnke AL, Seitz S, Hass D, Gancheva S, Kahl S, Yang B, Finan B, Schwarz K, Okun JG, Roden M, Blüher M, Müller TD, Krahmer N, Behrends C, Plettenburg O, Miaczynska M, Herzig S, Zeigerer A. Sekar R, et al. Among authors: finan b. Cell Metab. 2022 Dec 6;34(12):2047. doi: 10.1016/j.cmet.2022.10.013. Cell Metab. 2022. PMID: 36476936 Free article. No abstract available.
Targeted estrogen delivery reverses the metabolic syndrome.
Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, de Angelis MH, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH. Finan B, et al. Nat Med. 2012 Dec;18(12):1847-56. doi: 10.1038/nm.3009. Epub 2012 Nov 11. Nat Med. 2012. PMID: 23142820 Free PMC article.
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH. Müller TD, et al. Among authors: finan b. Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968. Nat Commun. 2013. PMID: 23744028 Free PMC article.
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485909
Current and Emerging Treatment Options in Diabetes Care.
Clemmensen C, Müller TD, Finan B, Tschöp MH, DiMarchi R. Clemmensen C, et al. Among authors: finan b. Handb Exp Pharmacol. 2016;233:437-59. doi: 10.1007/164_2015_7. Handb Exp Pharmacol. 2016. PMID: 25903416 Review.
Hypothalamic leptin action is mediated by histone deacetylase 5.
Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT. Kabra DG, et al. Among authors: finan b. Nat Commun. 2016 Feb 29;7:10782. doi: 10.1038/ncomms10782. Nat Commun. 2016. PMID: 26923837 Free PMC article.
93 results