Filippakopoulos P - Search Results

1

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.

Fujisawa T, Filippakopoulos P. Fujisawa T, et al. Among authors: filippakopoulos p. Nat Rev Mol Cell Biol. 2017 Apr;18(4):246-262. doi: 10.1038/nrm.2016.143. Epub 2017 Jan 5. Nat Rev Mol Cell Biol. 2017. PMID: 28053347 Review.

2

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S. Barr AJ, et al. Among authors: filippakopoulos p. Cell. 2009 Jan 23;136(2):352-63. doi: 10.1016/j.cell.2008.11.038. Cell. 2009. PMID: 19167335 Free PMC article.

3

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN. Filippakopoulos P, et al. J Mol Biol. 2010 Aug 20;401(3):389-402. doi: 10.1016/j.jmb.2010.06.017. Epub 2010 Jun 16. J Mol Biol. 2010. PMID: 20561531 Free PMC article.

4

Selective inhibition of BET bromodomains.

Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73. doi: 10.1038/nature09504. Epub 2010 Sep 24. Nature. 2010. PMID: 20871596 Free PMC article.

5

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.

Philpott M, Yang J, Tumber T, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Keates T, Felletar I, Ciulli A, Knapp S, Heightman TD. Philpott M, et al. Among authors: filippakopoulos p. Mol Biosyst. 2011 Oct;7(10):2899-908. doi: 10.1039/c1mb05099k. Epub 2011 Aug 1. Mol Biosyst. 2011. PMID: 21804994

6

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.

Hewings DS, Wang M, Philpott M, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Vuppusetty C, Marsden B, Knapp S, Conway SJ, Heightman TD. Hewings DS, et al. Among authors: filippakopoulos p. J Med Chem. 2011 Oct 13;54(19):6761-70. doi: 10.1021/jm200640v. Epub 2011 Sep 6. J Med Chem. 2011. PMID: 21851057 Free PMC article.

7

Bromodomains as therapeutic targets.

Muller S, Filippakopoulos P, Knapp S. Muller S, et al. Among authors: filippakopoulos p. Expert Rev Mol Med. 2011 Sep 13;13:e29. doi: 10.1017/S1462399411001992. Expert Rev Mol Med. 2011. PMID: 21933453 Free PMC article. Review.

8

Histone recognition and large-scale structural analysis of the human bromodomain family.

Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Filippakopoulos P, et al. Cell. 2012 Mar 30;149(1):214-31. doi: 10.1016/j.cell.2012.02.013. Cell. 2012. PMID: 22464331 Free PMC article.

9

The bromodomain interaction module.

Filippakopoulos P, Knapp S. Filippakopoulos P, et al. FEBS Lett. 2012 Aug 14;586(17):2692-704. doi: 10.1016/j.febslet.2012.04.045. Epub 2012 May 3. FEBS Lett. 2012. PMID: 22710155 Free article. Review.

10

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.

Ciceri P, Müller S, O'Mahony A, Fedorov O, Filippakopoulos P, Hunt JP, Lasater EA, Pallares G, Picaud S, Wells C, Martin S, Wodicka LM, Shah NP, Treiber DK, Knapp S. Ciceri P, et al. Among authors: filippakopoulos p. Nat Chem Biol. 2014 Apr;10(4):305-12. doi: 10.1038/nchembio.1471. Epub 2014 Mar 2. Nat Chem Biol. 2014. PMID: 24584101 Free PMC article.

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