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Page 1
Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.
Abbas S, Pich O, Devonshire G, Zamani SA, Katz-Summercorn A, Killcoyne S, Cheah C, Nutzinger B, Grehan N, Lopez-Bigas N; OCCAMS Consortium; Fitzgerald RC, Secrier M. Abbas S, et al. Nat Commun. 2023 Jul 15;14(1):4239. doi: 10.1038/s41467-023-39957-6. Nat Commun. 2023. PMID: 37454136 Free PMC article.
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas.
Ng AWT, Contino G, Killcoyne S, Devonshire G, Hsu R, Abbas S, Su J, Redmond AM, Weaver JMJ, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium; Edwards PAW, Fitzgerald RC. Ng AWT, et al. Commun Biol. 2022 Apr 8;5(1):335. doi: 10.1038/s42003-022-03238-7. Commun Biol. 2022. PMID: 35396535 Free PMC article.
Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus.
Knight WRC, McEwen R, Byrne BE, Habib W, Bott R, Zylstra J, Mahadeva U, Gossage JA; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium. Knight WRC, et al. Eur J Surg Oncol. 2020 Dec;46(12):2257-2261. doi: 10.1016/j.ejso.2020.07.003. Epub 2020 Jul 28. Eur J Surg Oncol. 2020. PMID: 32814680
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma.
Mourikis TP, Benedetti L, Foxall E, Temelkovski D, Nulsen J, Perner J, Cereda M, Lagergren J, Howell M, Yau C, Fitzgerald RC, Scaffidi P; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium; Ciccarelli FD. Mourikis TP, et al. Nat Commun. 2019 Jul 15;10(1):3101. doi: 10.1038/s41467-019-10898-3. Nat Commun. 2019. PMID: 31308377 Free PMC article.
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic.
Frankell AM, Jammula S, Li X, Contino G, Killcoyne S, Abbas S, Perner J, Bower L, Devonshire G, Ococks E, Grehan N, Mok J, O'Donovan M, MacRae S, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium; Fitzgerald RC. Frankell AM, et al. Nat Genet. 2019 Mar;51(3):506-516. doi: 10.1038/s41588-018-0331-5. Epub 2019 Feb 4. Nat Genet. 2019. PMID: 30718927 Free PMC article.
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma.
Turkington RC, Knight LA, Blayney JK, Secrier M, Douglas R, Parkes EE, Sutton EK, Stevenson L, McManus D, Halliday S, McCavigan AM, Logan GE, Walker SM, Steele CJ, Perner J, Bornschein J, MacRae S, Miremadi A, McCarron E, McQuaid S, Arthur K, James JA, Eatock MM, O'Neill R, Noble F, Underwood TJ, Harkin DP, Salto-Tellez M, Fitzgerald RC, Kennedy RD; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group. Turkington RC, et al. Gut. 2019 Nov;68(11):1918-1927. doi: 10.1136/gutjnl-2018-317624. Epub 2019 Mar 9. Gut. 2019. PMID: 30852560 Free PMC article.
Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data.
Jammula S, Katz-Summercorn AC, Li X, Linossi C, Smyth E, Killcoyne S, Biasci D, Subash VV, Abbas S, Blasko A, Devonshire G, Grantham A, Wronowski F, O'Donovan M, Grehan N, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium; Fitzgerald RC. Jammula S, et al. Gastroenterology. 2020 May;158(6):1682-1697.e1. doi: 10.1053/j.gastro.2020.01.044. Epub 2020 Feb 4. Gastroenterology. 2020. PMID: 32032585 Free PMC article.