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Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells.
Guarecuco R, Williams RT, Baudrier L, La K, Passarelli MC, Ekizoglu N, Mestanoglu M, Alwaseem H, Rostandy B, Fidelin J, Garcia-Bermudez J, Molina H, Birsoy K. Guarecuco R, et al. Among authors: fidelin j. Sci Adv. 2020 Oct 9;6(41):eabc7120. doi: 10.1126/sciadv.abc7120. Print 2020 Oct. Sci Adv. 2020. PMID: 33036978 Free PMC article.
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.
Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Garcia-Bermudez J, et al. Among authors: fidelin j. Nat Cell Biol. 2018 Jul;20(7):775-781. doi: 10.1038/s41556-018-0118-z. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941933 Free PMC article.
CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.
Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K. Zhu XG, et al. Among authors: fidelin j. Mol Cell. 2019 Apr 4;74(1):45-58.e7. doi: 10.1016/j.molcel.2019.01.037. Epub 2019 Mar 4. Mol Cell. 2019. PMID: 30846317 Free PMC article.