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Page 1
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, Fernandez de Orueta L, Torralba M, Fortun J, Vates R, Barberan J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, Gijon P, Monereo A, Abad D, Zuñiga S, Sola I, Rodon J, Vergara-Alert J, Izquierdo-Useros N, Fudio S, Pontes MJ, de Rivas B, Giron de Velasco P, Nieto A, Gomez J, Aviles P, Lubomirov R, Belgrano A, Sopesen B, White KM, Rosales R, Yildiz S, Reuschl AK, Thorne LG, Jolly C, Towers GJ, Zuliani-Alvarez L, Bouhaddou M, Obernier K, McGovern BL, Rodriguez ML, Enjuanes L, Fernandez-Sousa JM, Krogan NJ, Jimeno JM, Garcia-Sastre A. Varona JF, et al. Among authors: fernandez sousa jm. Life Sci Alliance. 2022 Jan 10;5(4):e202101200. doi: 10.26508/lsa.202101200. Print 2022 Apr. Life Sci Alliance. 2022. PMID: 35012962 Free PMC article. Clinical Trial.
Plitidepsin for the management of a cancer patient infected with SARS-CoV-2 while receiving chemotherapy.
Guisado-Vasco P, González-Cortijo L, D'Errico G, Serrera-Alvarez A, Sotres-Fernandez G, García-Coca M, Fernández-Sousa JM, Luepke-Estefan XE, López-Martín JA, Jimeno JM. Guisado-Vasco P, et al. Among authors: fernandez sousa jm. Ann Oncol. 2021 Oct;32(10):1295-1297. doi: 10.1016/j.annonc.2021.07.003. Epub 2021 Jul 7. Ann Oncol. 2021. PMID: 34242743 Free PMC article. No abstract available.
Plitidepsin as a successful rescue treatment for prolonged viral SARS-CoV-2 replication in a patient with previous anti-CD20 monoclonal antibody-mediated B cell depletion and chronic lymphocytic leukemia.
Guisado-Vasco P, Carralón-González MM, Aguareles-Gorines J, Martí-Ballesteros EM, Sánchez-Manzano MD, Carnevali-Ruiz D, García-Coca M, Barrena-Puertas R, de Viedma RG, Luque-Pinilla JM, Sotres-Fernandez G, Fernández-Sousa JM, Luepke-Estefan XE, López-Martín JA, Jimeno JM. Guisado-Vasco P, et al. Among authors: fernandez sousa jm. J Hematol Oncol. 2022 Jan 10;15(1):4. doi: 10.1186/s13045-021-01220-0. J Hematol Oncol. 2022. PMID: 35012608 Free PMC article.
Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.
Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, Martinez T, Fernandez-Sousa JM, Sanchez-Puelles JM, Munoz A. Cuadrado A, et al. Among authors: fernandez sousa jm. J Biol Chem. 2003 Jan 3;278(1):241-50. doi: 10.1074/jbc.M201010200. Epub 2002 Oct 31. J Biol Chem. 2003. PMID: 12414812 Free article.
Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.
Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, de Orueta LF, Torralba M, Fortún J, Vates R, Barberán J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, Gijón P, Monereo A, Abad D, Zúñiga S, Sola I, Rodon J, Izquierdo-Useros N, Fudio S, Pontes MJ, de Rivas B, Girón de Velasco P, Sopesén B, Nieto A, Gómez J, Avilés P, Lubomirov R, White KM, Rosales R, Yildiz S, Reuschl AK, Thorne LG, Jolly C, Towers GJ, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Enjuanes L, Fernández-Sousa JM; Plitidepsin – COVID - 19 Study Group; Krogan NJ, Jimeno JM, García-Sastre A. Varona JF, et al. Among authors: fernandez sousa jm. medRxiv [Preprint]. 2021 May 25:2021.05.25.21257505. doi: 10.1101/2021.05.25.21257505. medRxiv. 2021. PMID: 34075384 Free PMC article. Updated. Preprint.
Screening for new compounds with antiherpes activity.
Alarcón B, Lacal JC, Fernández-Sousa JM, Carrasco L. Alarcón B, et al. Among authors: fernandez sousa jm. Antiviral Res. 1984 Oct;4(5):231-44. doi: 10.1016/0166-3542(84)90029-9. Antiviral Res. 1984. PMID: 6517562
21 results