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Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models.
Costa-Machado LF, Garcia-Dominguez E, McIntyre RL, Lopez-Aceituno JL, Ballesteros-Gonzalez Á, Tapia-Gonzalez A, Fabregat-Safont D, Eisenberg T, Gomez J, Plaza A, Sierra-Ramirez A, Perez M, Villanueva-Bermejo D, Fornari T, Loza MI, Herradon G, Hofer SJ, Magnes C, Madeo F, Duerr JS, Pozo OJ, Galindo MI, Del Pino I, Houtkooper RH, Megias D, Viña J, Gomez-Cabrera MC, Fernandez-Marcos PJ. Costa-Machado LF, et al. Among authors: fernandez marcos pj. Nat Commun. 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y. Nat Commun. 2023. PMID: 37188705 Free PMC article.
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA. Tomás-Loba A, et al. Cell. 2008 Nov 14;135(4):609-22. doi: 10.1016/j.cell.2008.09.034. Cell. 2008. PMID: 19013273 Free article.
G6PD protects from oxidative damage and improves healthspan in mice.
Nóbrega-Pereira S, Fernandez-Marcos PJ, Brioche T, Gomez-Cabrera MC, Salvador-Pascual A, Flores JM, Viña J, Serrano M. Nóbrega-Pereira S, et al. Nat Commun. 2016 Mar 15;7:10894. doi: 10.1038/ncomms10894. Nat Commun. 2016. PMID: 26976705 Free PMC article.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Costa-Machado LF, Martín-Hernández R, Sanchez-Luengo MÁ, Hess K, Vales-Villamarin C, Barradas M, Lynch C, de la Nava D, Diaz-Ruiz A, de Cabo R, Cañamero M, Martinez L, Sanchez-Carbayo M, Herranz D, Serrano M, Fernandez-Marcos PJ. Costa-Machado LF, et al. EMBO Rep. 2018 Sep;19(9):e43879. doi: 10.15252/embr.201643879. Epub 2018 Jul 18. EMBO Rep. 2018. PMID: 30021836 Free PMC article.
The sirtuin family in cancer.
Costa-Machado LF, Fernandez-Marcos PJ. Costa-Machado LF, et al. Cell Cycle. 2019 Sep;18(18):2164-2196. doi: 10.1080/15384101.2019.1634953. Epub 2019 Jul 25. Cell Cycle. 2019. PMID: 31251117 Free PMC article.
Identification and characterization of Cardiac Glycosides as senolytic compounds.
Triana-Martínez F, Picallos-Rabina P, Da Silva-Álvarez S, Pietrocola F, Llanos S, Rodilla V, Soprano E, Pedrosa P, Ferreirós A, Barradas M, Hernández-González F, Lalinde M, Prats N, Bernadó C, González P, Gómez M, Ikonomopoulou MP, Fernández-Marcos PJ, García-Caballero T, Del Pino P, Arribas J, Vidal A, González-Barcia M, Serrano M, Loza MI, Domínguez E, Collado M. Triana-Martínez F, et al. Nat Commun. 2019 Oct 21;10(1):4731. doi: 10.1038/s41467-019-12888-x. Nat Commun. 2019. PMID: 31636264 Free PMC article.
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