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Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice.
Pastor-Fernández A, Bertos AR, Sierra-Ramírez A, Del Moral-Salmoral J, Merino J, de Ávila AI, Olagüe C, Villares R, González-Aseguinolaza G, Rodríguez MÁ, Fresno M, Gironés N, Bustos M, Smerdou C, Fernandez-Marcos PJ, von Kobbe C. Pastor-Fernández A, et al. Among authors: fernandez marcos pj. Aging Cell. 2023 Mar;22(3):e13771. doi: 10.1111/acel.13771. Epub 2023 Jan 26. Aging Cell. 2023. PMID: 36704839 Free PMC article.
PI3Kα inhibition reduces obesity in mice.
Lopez-Guadamillas E, Muñoz-Martin M, Martinez S, Pastor J, Fernandez-Marcos PJ, Serrano M. Lopez-Guadamillas E, et al. Aging (Albany NY). 2016 Nov 4;8(11):2747-2753. doi: 10.18632/aging.101075. Aging (Albany NY). 2016. PMID: 27816049 Free PMC article.
Production of Fucoxanthin from Phaeodactylum tricornutum Using High Performance Countercurrent Chromatography Retaining Its FOXO3 Nuclear Translocation-Inducing Effect.
Bárcenas-Pérez D, Střížek A, Hrouzek P, Kopecký J, Barradas M, Sierra-Ramirez A, Fernandez-Marcos PJ, Cheel J. Bárcenas-Pérez D, et al. Among authors: fernandez marcos pj. Mar Drugs. 2021 Sep 11;19(9):517. doi: 10.3390/md19090517. Mar Drugs. 2021. PMID: 34564179 Free PMC article.
p21 is necessary for the beneficial effects of fasting during chemotherapy.
Plaza A, Pastor-Fernández A, López-Aceituno JL, Barradas M, Pantoja C, Fernandez-Marcos PJ. Plaza A, et al. Among authors: fernandez marcos pj. Cancer Commun (Lond). 2023 Jan;43(1):164-168. doi: 10.1002/cac2.12384. Epub 2022 Nov 4. Cancer Commun (Lond). 2023. PMID: 36331275 Free PMC article. No abstract available.
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice.
Rodriguez-Ramiro I, Pastor-Fernández A, López-Aceituno JL, Garcia-Dominguez E, Sierra-Ramirez A, Valverde AM, Martinez-Pastor B, Efeyan A, Gomez-Cabrera MC, Viña J, Fernandez-Marcos PJ. Rodriguez-Ramiro I, et al. Among authors: fernandez marcos pj. Free Radic Biol Med. 2024 Jan;210:448-461. doi: 10.1016/j.freeradbiomed.2023.11.019. Epub 2023 Nov 29. Free Radic Biol Med. 2024. PMID: 38036067 Free article.
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA. Tomás-Loba A, et al. Cell. 2008 Nov 14;135(4):609-22. doi: 10.1016/j.cell.2008.09.034. Cell. 2008. PMID: 19013273 Free article.
Identification and characterization of Cardiac Glycosides as senolytic compounds.
Triana-Martínez F, Picallos-Rabina P, Da Silva-Álvarez S, Pietrocola F, Llanos S, Rodilla V, Soprano E, Pedrosa P, Ferreirós A, Barradas M, Hernández-González F, Lalinde M, Prats N, Bernadó C, González P, Gómez M, Ikonomopoulou MP, Fernández-Marcos PJ, García-Caballero T, Del Pino P, Arribas J, Vidal A, González-Barcia M, Serrano M, Loza MI, Domínguez E, Collado M. Triana-Martínez F, et al. Nat Commun. 2019 Oct 21;10(1):4731. doi: 10.1038/s41467-019-12888-x. Nat Commun. 2019. PMID: 31636264 Free PMC article.
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation.
Blázquez-Prieto J, Huidobro C, López-Alonso I, Amado-Rodriguez L, Martín-Vicente P, López-Martínez C, Crespo I, Pantoja C, Fernandez-Marcos PJ, Serrano M, Sznajder JI, Albaiceta GM. Blázquez-Prieto J, et al. Transl Res. 2021 Jul;233:104-116. doi: 10.1016/j.trsl.2021.01.008. Epub 2021 Jan 27. Transl Res. 2021. PMID: 33515780 Free PMC article.
52 results