Fernandez CO - Search Results

1

Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.

González-Lizárraga F, Socías SB, Ávila CL, Torres-Bugeau CM, Barbosa LR, Binolfi A, Sepúlveda-Díaz JE, Del-Bel E, Fernandez CO, Papy-Garcia D, Itri R, Raisman-Vozari R, Chehín RN. González-Lizárraga F, et al. Among authors: fernandez co. Sci Rep. 2017 Feb 3;7:41755. doi: 10.1038/srep41755. Sci Rep. 2017. PMID: 28155912 Free PMC article.

2

Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement.

Binolfi A, Rasia RM, Bertoncini CW, Ceolin M, Zweckstetter M, Griesinger C, Jovin TM, Fernández CO. Binolfi A, et al. Among authors: fernandez co. J Am Chem Soc. 2006 Aug 2;128(30):9893-901. doi: 10.1021/ja0618649. J Am Chem Soc. 2006. PMID: 16866548

3

Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation.

Bertoncini CW, Rasia RM, Lamberto GR, Binolfi A, Zweckstetter M, Griesinger C, Fernandez CO. Bertoncini CW, et al. Among authors: fernandez co. J Mol Biol. 2007 Sep 21;372(3):708-22. doi: 10.1016/j.jmb.2007.07.009. Epub 2007 Jul 17. J Mol Biol. 2007. PMID: 17681539

4

Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation.

Binolfi A, Lamberto GR, Duran R, Quintanar L, Bertoncini CW, Souza JM, Cerveñansky C, Zweckstetter M, Griesinger C, Fernández CO. Binolfi A, et al. Among authors: fernandez co. J Am Chem Soc. 2008 Sep 3;130(35):11801-12. doi: 10.1021/ja803494v. Epub 2008 Aug 9. J Am Chem Soc. 2008. PMID: 18693689

5

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation.

Lamberto GR, Binolfi A, Orcellet ML, Bertoncini CW, Zweckstetter M, Griesinger C, Fernández CO. Lamberto GR, et al. Among authors: fernandez co. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21057-62. doi: 10.1073/pnas.0902603106. Epub 2009 Nov 30. Proc Natl Acad Sci U S A. 2009. PMID: 19948969 Free PMC article.

6

Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.

Binolfi A, Rodriguez EE, Valensin D, D'Amelio N, Ippoliti E, Obal G, Duran R, Magistrato A, Pritsch O, Zweckstetter M, Valensin G, Carloni P, Quintanar L, Griesinger C, Fernández CO. Binolfi A, et al. Among authors: fernandez co. Inorg Chem. 2010 Nov 15;49(22):10668-79. doi: 10.1021/ic1016752. Epub 2010 Oct 22. Inorg Chem. 2010. PMID: 20964419

7

Exploring the structural details of Cu(I) binding to α-synuclein by NMR spectroscopy.

Binolfi A, Valiente-Gabioud AA, Duran R, Zweckstetter M, Griesinger C, Fernandez CO. Binolfi A, et al. Among authors: fernandez co. J Am Chem Soc. 2011 Jan 19;133(2):194-6. doi: 10.1021/ja107842f. Epub 2010 Dec 15. J Am Chem Soc. 2011. PMID: 21158432

8

Recognition between a short unstructured peptide and a partially folded fragment leads to the thioredoxin fold sharing native-like dynamics.

Binolfi A, Fernández CO, Sica MP, Delfino JM, Santos J. Binolfi A, et al. Among authors: fernandez co. Proteins. 2012 May;80(5):1448-64. doi: 10.1002/prot.24043. Epub 2012 Mar 1. Proteins. 2012. PMID: 22383256

9

Structural basis behind the interaction of Zn²⁺ with the protein α-synuclein and the Aβ peptide: a comparative analysis.

Valiente-Gabioud AA, Torres-Monserrat V, Molina-Rubino L, Binolfi A, Griesinger C, Fernández CO. Valiente-Gabioud AA, et al. Among authors: fernandez co. J Inorg Biochem. 2012 Dec;117:334-41. doi: 10.1016/j.jinorgbio.2012.06.011. Epub 2012 Jun 29. J Inorg Biochem. 2012. PMID: 22832069

10

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

Miotto MC, Rodriguez EE, Valiente-Gabioud AA, Torres-Monserrat V, Binolfi A, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO. Miotto MC, et al. Among authors: fernandez co. Inorg Chem. 2014 May 5;53(9):4350-8. doi: 10.1021/ic4031377. Epub 2014 Apr 11. Inorg Chem. 2014. PMID: 24725094

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