Fernandes JPS - Search Results

1

Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi.

Varela MT, Amaral M, Romanelli MM, de Castro Levatti EV, Tempone AG, Fernandes JPS. Varela MT, et al. Among authors: fernandes jps. Eur J Pharm Sci. 2022 Apr 1;171:106114. doi: 10.1016/j.ejps.2021.106114. Epub 2022 Jan 2. Eur J Pharm Sci. 2022. PMID: 34986415 Free article.

2

Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.

Varela MT, Dias RZ, Martins LF, Ferreira DD, Tempone AG, Ueno AK, Lago JH, Fernandes JP. Varela MT, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1180-3. doi: 10.1016/j.bmcl.2016.01.040. Epub 2016 Jan 16. Bioorg Med Chem Lett. 2016. PMID: 26821820

3

New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum.

Varela MT, Lima ML, Galuppo MK, Tempone AG, de Oliveira A, Lago JHG, Fernandes JPS. Varela MT, et al. Among authors: fernandes jps. Chem Biol Drug Des. 2017 Nov;90(5):1007-1011. doi: 10.1111/cbdd.12986. Epub 2017 May 3. Chem Biol Drug Des. 2017. PMID: 28371557

4

Natural Products: Key Prototypes to Drug Discovery Against Neglected Diseases Caused by Trypanosomatids.

Varela MT, Fernandes JPS. Varela MT, et al. Among authors: fernandes jps. Curr Med Chem. 2020;27(13):2133-2146. doi: 10.2174/0929867325666180501102450. Curr Med Chem. 2020. PMID: 29714138 Review.

5

Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives.

Varela MT, Costa-Silva TA, Lago JHG, Tempone AG, Fernandes JPS. Varela MT, et al. Among authors: fernandes jps. Bioorg Chem. 2019 Aug;89:102996. doi: 10.1016/j.bioorg.2019.102996. Epub 2019 May 18. Bioorg Chem. 2019. PMID: 31132603

6

Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta.

Ginoza M, Fernandes GAB, Corrêa MF, Fernandes JPS. Ginoza M, et al. Among authors: fernandes jps, fernandes gab. Eur J Pharm Sci. 2020 Feb 15;143:105171. doi: 10.1016/j.ejps.2019.105171. Epub 2019 Dec 2. Eur J Pharm Sci. 2020. PMID: 31805391

7

Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A.

Morais TR, Conserva GAA, Varela MT, Costa-Silva TA, Thevenard F, Ponci V, Fortuna A, Falcão AC, Tempone AG, Fernandes JPS, Lago JHG. Morais TR, et al. Among authors: fernandes jps. Sci Rep. 2020 Mar 25;10(1):5467. doi: 10.1038/s41598-020-62352-w. Sci Rep. 2020. PMID: 32214193 Free PMC article.

8

Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity.

Oliveira L, Ferrarini M, Dos Santos AP, Varela MT, Corrêa ITS, Tempone AG, Melhem MSC, Vallim MA, Fernandes JPS, Pascon RC. Oliveira L, et al. Among authors: fernandes jps. Eur J Pharm Sci. 2020 Oct 1;153:105473. doi: 10.1016/j.ejps.2020.105473. Epub 2020 Jul 18. Eur J Pharm Sci. 2020. PMID: 32693012

9

Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches.

Varela MT, Ferrarini M, Mercaldi VG, Sufi BDS, Padovani G, Nazato LIS, Fernandes JPS. Varela MT, et al. Among authors: fernandes jps. Bioorg Chem. 2020 Oct;103:104108. doi: 10.1016/j.bioorg.2020.104108. Epub 2020 Jul 21. Bioorg Chem. 2020. PMID: 32750608

10

Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H₃ and H₄ receptors.

Corrêa MF, Balico-Silva AL, Kiss DJ, Fernandes GAB, Maraschin JC, Parreiras-E-Silva LT, Varela MT, Simões SC, Bouvier M, Keserű GM, Costa-Neto CM, Fernandes JPS. Corrêa MF, et al. Among authors: fernandes jps, fernandes gab. Bioorg Med Chem. 2021 Jan 15;30:115924. doi: 10.1016/j.bmc.2020.115924. Epub 2020 Dec 8. Bioorg Med Chem. 2021. PMID: 33333448

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