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Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Robles-Valero J, Fernández-Nevado L, Cuadrado M, Lorenzo-Martín LF, Fernández-Pisonero I, Abad A, Redín E, Montuenga L, Martín-Zanca D, Bigas A, Mallo M, Dosil M, Bustelo XR. Robles-Valero J, et al. Among authors: fernandez pisonero i. Mol Oncol. 2022 Oct;16(19):3533-3553. doi: 10.1002/1878-0261.13295. Epub 2022 Aug 30. Mol Oncol. 2022. PMID: 35895495 Free PMC article.
R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.
Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B. Mendoza P, et al. Sci Signal. 2018 May 29;11(532):eaal1506. doi: 10.1126/scisignal.aal1506. Sci Signal. 2018. PMID: 29844052
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.
Lorenzo-Martín LF, Citterio C, Menacho-Márquez M, Conde J, Larive RM, Rodríguez-Fdez S, García-Escudero R, Robles-Valero J, Cuadrado M, Fernández-Pisonero I, Dosil M, Sevilla MA, Montero MJ, Fernández-Salguero PM, Paramio JM, Bustelo XR. Lorenzo-Martín LF, et al. Among authors: fernandez pisonero i. Oncogene. 2019 Jan;38(2):209-227. doi: 10.1038/s41388-018-0433-7. Epub 2018 Aug 7. Oncogene. 2019. PMID: 30087437 Free PMC article.
An unexpected tumor suppressor role for VAV1a.
Bustelo XR, Lorenzo-Martín LF, Cuadrado M, Fernández-Pisonero I, Robles-Valero J. Bustelo XR, et al. Among authors: fernandez pisonero i. Mol Cell Oncol. 2018 Feb 23;5(3):e1432257. doi: 10.1080/23723556.2018.1432257. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250888 Free PMC article.
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
Rodríguez-Fdez S, Lorenzo-Martín LF, Fernández-Pisonero I, Porteiro B, Veyrat-Durebex C, Beiroa D, Al-Massadi O, Abad A, Diéguez C, Coppari R, Nogueiras R, Bustelo XR. Rodríguez-Fdez S, et al. Among authors: fernandez pisonero i. Nat Commun. 2020 Nov 16;11(1):5808. doi: 10.1038/s41467-020-19489-z. Nat Commun. 2020. PMID: 33199701 Free PMC article.
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