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Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome.
Rahim I, Sayed RK, Fernández-Ortiz M, Aranda-Martínez P, Guerra-Librero A, Fernández-Martínez J, Rusanova I, Escames G, Djerdjouri B, Acuña-Castroviejo D. Rahim I, et al. Naunyn Schmiedebergs Arch Pharmacol. 2021 Feb;394(2):261-277. doi: 10.1007/s00210-020-01972-5. Epub 2020 Sep 16. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 32936353
Melatonin, clock genes and mitochondria in sepsis.
Acuña-Castroviejo D, Rahim I, Acuña-Fernández C, Fernández-Ortiz M, Solera-Marín J, Sayed RKA, Díaz-Casado ME, Rusanova I, López LC, Escames G. Acuña-Castroviejo D, et al. Cell Mol Life Sci. 2017 Nov;74(21):3965-3987. doi: 10.1007/s00018-017-2610-1. Epub 2017 Aug 7. Cell Mol Life Sci. 2017. PMID: 28785808 Review.
Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin.
Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Aranda-Martínez P, Fernández-Martínez J, Guerra-Librero A, Escames G, López LC, Alsaadawy RM, Acuña-Castroviejo D. Sayed RKA, et al. J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1699-1708. doi: 10.1093/gerona/glz079. J Gerontol A Biol Sci Med Sci. 2019. PMID: 30869745
Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging.
Fernández-Ortiz M, Sayed RKA, Fernández-Martínez J, Cionfrini A, Aranda-Martínez P, Escames G, de Haro T, Acuña-Castroviejo D. Fernández-Ortiz M, et al. Antioxidants (Basel). 2020 Nov 27;9(12):1187. doi: 10.3390/antiox9121187. Antioxidants (Basel). 2020. PMID: 33260800 Free PMC article.
The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle.
Sayed RK, Fernández-Ortiz M, Fernández-Martínez J, Aranda Martínez P, Guerra-Librero A, Rodríguez-Santana C, de Haro T, Escames G, Acuña-Castroviejo D, Rusanova I. Sayed RK, et al. Among authors: fernandez ortiz m. Antioxidants (Basel). 2021 Mar 27;10(4):524. doi: 10.3390/antiox10040524. Antioxidants (Basel). 2021. PMID: 33801675 Free PMC article.
Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.
López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López LC, Acuña-Castroviejo D. López A, et al. PLoS One. 2017 Aug 11;12(8):e0183090. doi: 10.1371/journal.pone.0183090. eCollection 2017. PLoS One. 2017. PMID: 28800639 Free PMC article.
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