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Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson's disease.
Pons-Espinal M, Blasco-Agell L, Fernandez-Carasa I, Andrés-Benito P, di Domenico A, Richaud-Patin Y, Baruffi V, Marruecos L, Espinosa L, Garrido A, Tolosa E, Edel MJ, Otero MJ, Mosquera JL, Ferrer I, Raya A, Consiglio A. Pons-Espinal M, et al. Among authors: fernandez carasa i. JCI Insight. 2024 Feb 8;9(3):e163359. doi: 10.1172/jci.insight.163359. JCI Insight. 2024. PMID: 38329129 Free PMC article.
Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock-in mouse model.
Jung-Kc K, Tristán-Noguero A, Altankhuyag A, Piñol Belenguer D, Prestegård KS, Fernandez-Carasa I, Colini Baldeschi A, Sigatulina Bondarenko M, García-Cazorla A, Consiglio A, Martinez A. Jung-Kc K, et al. Among authors: fernandez carasa i. J Inherit Metab Dis. 2024 May;47(3):494-508. doi: 10.1002/jimd.12702. Epub 2024 Jan 9. J Inherit Metab Dis. 2024. PMID: 38196161
iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation.
Tristán-Noguero A, Fernández-Carasa I, Calatayud C, Bermejo-Casadesús C, Pons-Espinal M, Colini Baldeschi A, Campa L, Artigas F, Bortolozzi A, Domingo-Jiménez R, Ibáñez S, Pineda M, Artuch R, Raya Á, García-Cazorla À, Consiglio A. Tristán-Noguero A, et al. Among authors: fernandez carasa i. EMBO Mol Med. 2023 Mar 8;15(3):e15847. doi: 10.15252/emmm.202215847. Epub 2023 Feb 6. EMBO Mol Med. 2023. PMID: 36740977 Free PMC article.
Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson's Disease Patient-Specific Dopamine Neurons.
Ferrer-Lorente R, Lozano-Cruz T, Fernández-Carasa I, Miłowska K, de la Mata FJ, Bryszewska M, Consiglio A, Ortega P, Gómez R, Raya A. Ferrer-Lorente R, et al. Among authors: fernandez carasa i. Biomacromolecules. 2021 Nov 8;22(11):4582-4591. doi: 10.1021/acs.biomac.1c00884. Epub 2021 Oct 6. Biomacromolecules. 2021. PMID: 34613701 Free PMC article.
Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration.
Carola G, Malagarriga D, Calatayud C, Pons-Espinal M, Blasco-Agell L, Richaud-Patin Y, Fernandez-Carasa I, Baruffi V, Beltramone S, Molina E, Dell'Era P, Toledo-Aral JJ, Tolosa E, Muotri AR, Garcia Ojalvo J, Soriano J, Raya A, Consiglio A. Carola G, et al. Among authors: fernandez carasa i. NPJ Parkinsons Dis. 2021 Jul 2;7(1):55. doi: 10.1038/s41531-021-00198-3. NPJ Parkinsons Dis. 2021. PMID: 34215735 Free PMC article.
Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases.
Cai R, Zhang Y, Simmering JE, Schultz JL, Li Y, Fernandez-Carasa I, Consiglio A, Raya A, Polgreen PM, Narayanan NS, Yuan Y, Chen Z, Su W, Han Y, Zhao C, Gao L, Ji X, Welsh MJ, Liu L. Cai R, et al. Among authors: fernandez carasa i. J Clin Invest. 2019 Oct 1;129(10):4539-4549. doi: 10.1172/JCI129987. J Clin Invest. 2019. PMID: 31524631 Free PMC article.
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Calatayud C, Carola G, Fernández-Carasa I, Valtorta M, Jiménez-Delgado S, Díaz M, Soriano-Fradera J, Cappelletti G, García-Sancho J, Raya Á, Consiglio A. Calatayud C, et al. Among authors: fernandez carasa i. Sci Rep. 2019 May 2;9(1):6811. doi: 10.1038/s41598-019-43080-2. Sci Rep. 2019. PMID: 31048719 Free PMC article.
Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease.
di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Muñoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M, Faella A, Parameswaran J, Soriano J, Ferrer I, Tolosa E, Zorzano A, Cuervo AM, Raya A, Consiglio A. di Domenico A, et al. Among authors: fernandez carasa i. Stem Cell Reports. 2019 Feb 12;12(2):213-229. doi: 10.1016/j.stemcr.2018.12.011. Epub 2019 Jan 10. Stem Cell Reports. 2019. PMID: 30639209 Free PMC article.
Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector.
Suh H, Zhou QG, Fernandez-Carasa I, Clemenson GD Jr, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH, Consiglio A. Suh H, et al. Among authors: fernandez carasa i. Front Mol Neurosci. 2018 Nov 15;11:415. doi: 10.3389/fnmol.2018.00415. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30498432 Free PMC article.
13 results