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Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.
Sevillano AM, Fernández-Borges N, Younas N, Wang F, R Elezgarai S, Bravo S, Vázquez-Fernández E, Rosa I, Eraña H, Gil D, Veiga S, Vidal E, Erickson-Beltran ML, Guitián E, Silva CJ, Nonno R, Ma J, Castilla J, R Requena J. Sevillano AM, et al. PLoS Pathog. 2018 Jan 31;14(1):e1006797. doi: 10.1371/journal.ppat.1006797. eCollection 2018 Jan. PLoS Pathog. 2018. PMID: 29385212 Free PMC article.
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.
Eraña H, Charco JM, Di Bari MA, Díaz-Domínguez CM, López-Moreno R, Vidal E, González-Miranda E, Pérez-Castro MA, García-Martínez S, Bravo S, Fernández-Borges N, Geijo M, D'Agostino C, Garrido J, Bian J, König A, Uluca-Yazgi B, Sabate R, Khaychuk V, Vanni I, Telling GC, Heise H, Nonno R, Requena JR, Castilla J. Eraña H, et al. Among authors: fernandez borges n. PLoS Pathog. 2019 Oct 23;15(10):e1008117. doi: 10.1371/journal.ppat.1008117. eCollection 2019 Oct. PLoS Pathog. 2019. PMID: 31644574 Free PMC article.
Cofactors influence the biological properties of infectious recombinant prions.
Fernández-Borges N, Di Bari MA, Eraña H, Sánchez-Martín M, Pirisinu L, Parra B, Elezgarai SR, Vanni I, López-Moreno R, Vaccari G, Venegas V, Charco JM, Gil D, Harrathi C, D'Agostino C, Agrimi U, Mayoral T, Requena JR, Nonno R, Castilla J. Fernández-Borges N, et al. Acta Neuropathol. 2018 Feb;135(2):179-199. doi: 10.1007/s00401-017-1782-y. Epub 2017 Nov 1. Acta Neuropathol. 2018. PMID: 29094186
Unraveling the key to the resistance of canids to prion diseases.
Fernández-Borges N, Parra B, Vidal E, Eraña H, Sánchez-Martín MA, de Castro J, Elezgarai SR, Pumarola M, Mayoral T, Castilla J. Fernández-Borges N, et al. PLoS Pathog. 2017 Nov 13;13(11):e1006716. doi: 10.1371/journal.ppat.1006716. eCollection 2017 Nov. PLoS Pathog. 2017. PMID: 29131852 Free PMC article.
A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models.
Otero A, Hedman C, Fernández-Borges N, Eraña H, Marín B, Monzón M, Sánchez-Martín MA, Nonno R, Badiola JJ, Bolea R, Castilla J. Otero A, et al. Among authors: fernandez borges n. Mol Neurobiol. 2019 Sep;56(9):6501-6511. doi: 10.1007/s12035-019-1535-0. Epub 2019 Mar 7. Mol Neurobiol. 2019. PMID: 30847740
In vitro studies of the transmission barrier.
Fernández-Borges N, de Castro J, Castilla J. Fernández-Borges N, et al. Prion. 2009 Oct-Dec;3(4):220-3. doi: 10.4161/pri.3.4.10500. Epub 2009 Oct 30. Prion. 2009. PMID: 20009509 Free PMC article. Review.
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