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Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.
Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA. Cuyàs E, et al. Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8. Aging Cell. 2018. PMID: 29740925 Free PMC article.
Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients.
Cuyàs E, Fernández-Arroyo S, Buxó M, Pernas S, Dorca J, Álvarez I, Martínez S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S, Luque M, Morilla I, Stradella A, Viñas G, Cortés J, Verdura S, Brunet J, López-Bonet E, Garcia M, Saidani S, Joven J, Martin-Castillo B, Menendez JA. Cuyàs E, et al. Aging (Albany NY). 2019 May 9;11(9):2874-2888. doi: 10.18632/aging.101960. Aging (Albany NY). 2019. PMID: 31076561 Free PMC article. Clinical Trial.
Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.
Cuyàs E, Fernández-Arroyo S, Corominas-Faja B, Rodríguez-Gallego E, Bosch-Barrera J, Martin-Castillo B, De Llorens R, Joven J, Menendez JA. Cuyàs E, et al. Oncotarget. 2015 May 20;6(14):12279-96. doi: 10.18632/oncotarget.3733. Oncotarget. 2015. PMID: 25980580 Free PMC article.
Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study.
Riera-Borrull M, García-Heredia A, Fernández-Arroyo S, Hernández-Aguilera A, Cabré N, Cuyàs E, Luciano-Mateo F, Camps J, Menendez JA, Joven J. Riera-Borrull M, et al. Int J Mol Sci. 2017 Oct 28;18(11):2263. doi: 10.3390/ijms18112263. Int J Mol Sci. 2017. PMID: 29143783 Free PMC article.
Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate.
Vazquez-Martin A, Van den Haute C, Cufí S, Corominas-Faja B, Cuyàs E, Lopez-Bonet E, Rodriguez-Gallego E, Fernández-Arroyo S, Joven J, Baekelandt V, Menendez JA. Vazquez-Martin A, et al. Aging (Albany NY). 2016 Jul;8(7):1330-52. doi: 10.18632/aging.100976. Aging (Albany NY). 2016. PMID: 27295498 Free PMC article.
71 results