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ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
Jimeno S, Prados-Carvajal R, Fernández-Ávila MJ, Silva S, Silvestris DA, Endara-Coll M, Rodríguez-Real G, Domingo-Prim J, Mejías-Navarro F, Romero-Franco A, Jimeno-González S, Barroso S, Cesarini V, Aguilera A, Gallo A, Visa N, Huertas P. Jimeno S, et al. Among authors: fernandez avila mj. Nat Commun. 2021 Sep 17;12(1):5512. doi: 10.1038/s41467-021-25790-2. Nat Commun. 2021. PMID: 34535666 Free PMC article.
New tools to study DNA double-strand break repair pathway choice.
Gomez-Cabello D, Jimeno S, Fernández-Ávila MJ, Huertas P. Gomez-Cabello D, et al. Among authors: fernandez avila mj. PLoS One. 2013 Oct 14;8(10):e77206. doi: 10.1371/journal.pone.0077206. eCollection 2013. PLoS One. 2013. PMID: 24155929 Free PMC article.
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection.
López-Saavedra A, Gómez-Cabello D, Domínguez-Sánchez MS, Mejías-Navarro F, Fernández-Ávila MJ, Dinant C, Martínez-Macías MI, Bartek J, Huertas P. López-Saavedra A, et al. Among authors: fernandez avila mj. Nat Commun. 2016 Aug 9;7:12364. doi: 10.1038/ncomms12364. Nat Commun. 2016. PMID: 27503537 Free PMC article.
The COP9 signalosome is vital for timely repair of DNA double-strand breaks.
Meir M, Galanty Y, Kashani L, Blank M, Khosravi R, Fernández-Ávila MJ, Cruz-García A, Star A, Shochot L, Thomas Y, Garrett LJ, Chamovitz DA, Bodine DM, Kurz T, Huertas P, Ziv Y, Shiloh Y. Meir M, et al. Among authors: fernandez avila mj. Nucleic Acids Res. 2015 May 19;43(9):4517-30. doi: 10.1093/nar/gkv270. Epub 2015 Apr 8. Nucleic Acids Res. 2015. PMID: 25855810 Free PMC article.