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Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma.
Bianchini F, Portioli E, Ferlenghi F, Vacondio F, Andreucci E, Biagioni A, Ruzzolini J, Peppicelli S, Lulli M, Calorini L, Battistini L, Zanardi F, Sartori A. Bianchini F, et al. Among authors: ferlenghi f. Cancer Lett. 2019 Apr 1;446:25-37. doi: 10.1016/j.canlet.2018.12.021. Epub 2019 Jan 11. Cancer Lett. 2019. PMID: 30639534
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR.
Castelli R, Bozza N, Cavazzoni A, Bonelli M, Vacondio F, Ferlenghi F, Callegari D, Silva C, Rivara S, Lodola A, Digiacomo G, Fumarola C, Alfieri R, Petronini PG, Mor M. Castelli R, et al. Among authors: ferlenghi f. Eur J Med Chem. 2019 Jan 15;162:507-524. doi: 10.1016/j.ejmech.2018.11.029. Epub 2018 Nov 13. Eur J Med Chem. 2019. PMID: 30472599
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties.
Incerti M, Russo S, Corrado M, Giorgio C, Ballabeni V, Chiodelli P, Rusnati M, Scalvini L, Callegari D, Castelli R, Vacondio F, Ferlenghi F, Tognolini M, Lodola A. Incerti M, et al. Among authors: ferlenghi f. Eur J Med Chem. 2020 Mar 1;189:112083. doi: 10.1016/j.ejmech.2020.112083. Epub 2020 Jan 22. Eur J Med Chem. 2020. PMID: 32000051
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo.
Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, Corelli F. Mugnaini C, et al. Among authors: ferlenghi f. J Med Chem. 2020 Jul 9;63(13):7369-7391. doi: 10.1021/acs.jmedchem.0c00595. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32515588
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph-Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice.
Ferlenghi F, Giorgio C, Incerti M, Guidetti L, Chiodelli P, Rusnati M, Tognolini M, Vacondio F, Mor M, Lodola A. Ferlenghi F, et al. Pharmaceuticals (Basel). 2021 Dec 28;15(1):41. doi: 10.3390/ph15010041. Pharmaceuticals (Basel). 2021. PMID: 35056098 Free PMC article.
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