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The profibrotic effects of MK-8617 on tubulointerstitial fibrosis mediated by the KLF5 regulating pathway.
Li ZL, Lv LL, Wang B, Tang TT, Feng Y, Cao JY, Jiang LQ, Sun YB, Liu H, Zhang XL, Ma KL, Tang RN, Liu BC. Li ZL, et al. Among authors: feng y. FASEB J. 2019 Nov;33(11):12630-12643. doi: 10.1096/fj.201901087RR. Epub 2019 Aug 26. FASEB J. 2019. PMID: 31451021 Free PMC article.
These findings provide novel insights into TIF induction by high-dose MK (HIF-PHI), suggesting that the safety dosage window needs to be emphasized in future clinical applications.-Li, Z.-L., Lv, L.-L., Wang, B., Tang, T.-T., Feng, Y., Cao, J.-Y., Jiang, L.-Q …
These findings provide novel insights into TIF induction by high-dose MK (HIF-PHI), suggesting that the safety dosage window needs to be emp …
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