Feng Y - Search Results

1

A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.

Feng Y, Chambers JW, Iqbal S, Koenig M, Park H, Cherry L, Hernandez P, Figuera-Losada M, LoGrasso PV. Feng Y, et al. ACS Chem Biol. 2013 Aug 16;8(8):1747-54. doi: 10.1021/cb3006165. Epub 2013 Jun 10. ACS Chem Biol. 2013. PMID: 23751758 Free PMC article.

2

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.

Zheng K, Park CM, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y. Zheng K, et al. Among authors: feng y. ACS Med Chem Lett. 2015 Mar 2;6(4):413-8. doi: 10.1021/ml500474d. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893042 Free PMC article.

3

Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.

LoGrasso PV, Feng Y. LoGrasso PV, et al. Among authors: feng y. Curr Top Med Chem. 2009;9(8):704-23. doi: 10.2174/156802609789044452. Curr Top Med Chem. 2009. PMID: 19689376 Review.

4

Amino acid derived quinazolines as Rock/PKA inhibitors.

Chowdhury S, Chen YT, Fang X, Grant W, Pocas J, Cameron MD, Ruiz C, Lin L, Park H, Schröter T, Bannister TD, Lograsso PV, Feng Y. Chowdhury S, et al. Among authors: feng y. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1592-9. doi: 10.1016/j.bmcl.2013.01.109. Epub 2013 Jan 31. Bioorg Med Chem Lett. 2013. PMID: 23416002

5

Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.

Yin Y, Lin L, Ruiz C, Khan S, Cameron MD, Grant W, Pocas J, Eid N, Park H, Schröter T, Lograsso PV, Feng Y. Yin Y, et al. Among authors: feng y. J Med Chem. 2013 May 9;56(9):3568-81. doi: 10.1021/jm400062r. Epub 2013 Apr 25. J Med Chem. 2013. PMID: 23570561

6

Rho kinase inhibitors: a patent review (2012 - 2013).

Feng Y, LoGrasso PV. Feng Y, et al. Expert Opin Ther Pat. 2014 Mar;24(3):295-307. doi: 10.1517/13543776.2014.863279. Epub 2013 Nov 27. Expert Opin Ther Pat. 2014. PMID: 24283930 Review.

7

Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.

Zheng K, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y. Zheng K, et al. Among authors: feng y. J Med Chem. 2014 Dec 11;57(23):10013-30. doi: 10.1021/jm501256y. Epub 2014 Nov 21. J Med Chem. 2014. PMID: 25393557 Free PMC article.

8

Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.

Yin Y, Zheng K, Eid N, Howard S, Jeong JH, Yi F, Guo J, Park CM, Bibian M, Wu W, Hernandez P, Park H, Wu Y, Luo JL, LoGrasso PV, Feng Y. Yin Y, et al. Among authors: feng y. J Med Chem. 2015 Feb 26;58(4):1846-61. doi: 10.1021/jm501680m. Epub 2015 Feb 4. J Med Chem. 2015. PMID: 25621531 Free PMC article.

9

Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.

Park H, Iqbal S, Hernandez P, Mora R, Zheng K, Feng Y, LoGrasso P. Park H, et al. Among authors: feng y. Sci Rep. 2015 Jan 27;5:8047. doi: 10.1038/srep08047. Sci Rep. 2015. PMID: 25623238 Free PMC article.

10

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

Feng Y, Yin Y, Weiser A, Griffin E, Cameron MD, Lin L, Ruiz C, Schürer SC, Inoue T, Rao PV, Schröter T, Lograsso P. Feng Y, et al. J Med Chem. 2008 Nov 13;51(21):6642-5. doi: 10.1021/jm800986w. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834107 Free PMC article.

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