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Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
Bioorg Med Chem. 2022 Jun 1;63:116729. doi: 10.1016/j.bmc.2022.116729. Epub 2022 Apr 2.
Bioorg Med Chem. 2022.
PMID: 35439688
Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs.
Jeffries B, Wang Z, Felstead HR, Le Questel JY, Scott JS, Chiarparin E, Graton J, Linclau B.
Jeffries B, et al. Among authors: felstead hr.
J Med Chem. 2020 Feb 13;63(3):1002-1031. doi: 10.1021/acs.jmedchem.9b01172. Epub 2020 Jan 17.
J Med Chem. 2020.
PMID: 31894985
Free article.
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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy.
Wang Z, Jeffries BF, Felstead HR, Wells NJ, Chiarparin E, Linclau B.
Wang Z, et al. Among authors: felstead hr.
J Vis Exp. 2019 Jan 30;(143). doi: 10.3791/58567.
J Vis Exp. 2019.
PMID: 30774129
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Lipophilicity Modulations by Fluorination Correlate with Membrane Partitioning.
Wang Z, Felstead HR, Troup RI, Linclau B, Williamson PTF.
Wang Z, et al. Among authors: felstead hr.
Angew Chem Int Ed Engl. 2023 May 15;62(21):e202301077. doi: 10.1002/anie.202301077. Epub 2023 Apr 17.
Angew Chem Int Ed Engl. 2023.
PMID: 36932824
Free PMC article.
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The Synthesis of Structurally Diverse Macrocycles By Successive Ring Expansion.
Kitsiou C, Hindes JJ, I'Anson P, Jackson P, Wilson TC, Daly EK, Felstead HR, Hearnshaw P, Unsworth WP.
Kitsiou C, et al. Among authors: felstead hr.
Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15794-8. doi: 10.1002/anie.201509153. Epub 2015 Nov 13.
Angew Chem Int Ed Engl. 2015.
PMID: 26768697
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