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Development of siRNA payloads to target KRAS-mutant cancer.
Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW. Yuan TL, et al. Among authors: fellmann c. Cancer Discov. 2014 Oct;4(10):1182-1197. doi: 10.1158/2159-8290.CD-13-0900. Epub 2014 Aug 6. Cancer Discov. 2014. PMID: 25100204 Free PMC article.
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.
Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW. Zuber J, et al. Among authors: fellmann c. Genes Dev. 2011 Aug 1;25(15):1628-40. doi: 10.1101/gad.17269211. Genes Dev. 2011. PMID: 21828272 Free PMC article.
A pipeline for the generation of shRNA transgenic mice.
Dow LE, Premsrirut PK, Zuber J, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW. Dow LE, et al. Among authors: fellmann c. Nat Protoc. 2012 Feb 2;7(2):374-93. doi: 10.1038/nprot.2011.446. Nat Protoc. 2012. PMID: 22301776 Free PMC article.
An optimized microRNA backbone for effective single-copy RNAi.
Fellmann C, Hoffmann T, Sridhar V, Hopfgartner B, Muhar M, Roth M, Lai DY, Barbosa IA, Kwon JS, Guan Y, Sinha N, Zuber J. Fellmann C, et al. Cell Rep. 2013 Dec 26;5(6):1704-13. doi: 10.1016/j.celrep.2013.11.020. Epub 2013 Dec 12. Cell Rep. 2013. PMID: 24332856 Free article.
Stable RNA interference rules for silencing.
Fellmann C, Lowe SW. Fellmann C, et al. Nat Cell Biol. 2014 Jan;16(1):10-8. doi: 10.1038/ncb2895. Nat Cell Biol. 2014. PMID: 24366030 Free PMC article. Review.
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.
Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N. Lito P, et al. Among authors: fellmann c. Cancer Cell. 2014 May 12;25(5):697-710. doi: 10.1016/j.ccr.2014.03.011. Epub 2014 Apr 17. Cancer Cell. 2014. PMID: 24746704 Free PMC article.
40 results