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Mitochondrial membrane lipidome defines yeast longevity.
Beach A, Richard VR, Leonov A, Burstein MT, Bourque SD, Koupaki O, Juneau M, Feldman R, Iouk T, Titorenko VI. Beach A, et al. Among authors: feldman r. Aging (Albany NY). 2013 Jul;5(7):551-74. doi: 10.18632/aging.100578. Aging (Albany NY). 2013. PMID: 23924582 Free PMC article.
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.
Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI. Beach A, et al. Among authors: feldman r. Cell Cycle. 2015;14(11):1643-56. doi: 10.1080/15384101.2015.1026493. Cell Cycle. 2015. PMID: 25839782 Free PMC article.
Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from "liponecrosis", a previously unknown form of programmed cell death.
Sheibani S, Richard VR, Beach A, Leonov A, Feldman R, Mattie S, Khelghatybana L, Piano A, Greenwood M, Vali H, Titorenko VI. Sheibani S, et al. Among authors: feldman r. Cell Cycle. 2014;13(1):138-47. doi: 10.4161/cc.26885. Epub 2013 Oct 28. Cell Cycle. 2014. PMID: 24196447 Free PMC article.
Mechanism of liponecrosis, a distinct mode of programmed cell death.
Richard VR, Beach A, Piano A, Leonov A, Feldman R, Burstein MT, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Baptista S, Campbell C, Goncharov D, Pannu S, Patrinos D, Sadri B, Svistkova V, Victor A, Titorenko VI. Richard VR, et al. Among authors: feldman r. Cell Cycle. 2014;13(23):3707-26. doi: 10.4161/15384101.2014.965003. Cell Cycle. 2014. PMID: 25483081 Free PMC article.
Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes.
Lutchman V, Medkour Y, Samson E, Arlia-Ciommo A, Dakik P, Cortes B, Feldman R, Mohtashami S, McAuley M, Chancharoen M, Rukundo B, Simard É, Titorenko VI. Lutchman V, et al. Among authors: feldman r. Oncotarget. 2016 Mar 29;7(13):16542-66. doi: 10.18632/oncotarget.7665. Oncotarget. 2016. PMID: 26918729 Free PMC article.
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.
Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI. Arlia-Ciommo A, et al. Among authors: feldman r. Oncotarget. 2018 Mar 5;9(22):16163-16184. doi: 10.18632/oncotarget.24604. eCollection 2018 Mar 23. Oncotarget. 2018. PMID: 29662634 Free PMC article.
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.
Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofigari-Esfahani N, Rosanelli L, Titorenko VI. Leonov A, et al. Among authors: feldman r. Oncotarget. 2017 Sep 1;8(41):69328-69350. doi: 10.18632/oncotarget.20614. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050207 Free PMC article.
2,190 results