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14-step synthesis of (+)-ingenol from (+)-3-carene.
Jørgensen L, McKerrall SJ, Kuttruff CA, Ungeheuer F, Felding J, Baran PS. Jørgensen L, et al. Among authors: felding j. Science. 2013 Aug 23;341(6148):878-82. doi: 10.1126/science.1241606. Epub 2013 Aug 1. Science. 2013. PMID: 23907534
Nineteen-step total synthesis of (+)-phorbol.
Kawamura S, Chu H, Felding J, Baran PS. Kawamura S, et al. Among authors: felding j. Nature. 2016 Apr 7;532(7597):90-3. doi: 10.1038/nature17153. Epub 2016 Mar 23. Nature. 2016. PMID: 27007853 Free PMC article.
Scalable Synthesis of (-)-Thapsigargin.
Chu H, Smith JM, Felding J, Baran PS. Chu H, et al. Among authors: felding j. ACS Cent Sci. 2017 Jan 25;3(1):47-51. doi: 10.1021/acscentsci.6b00313. Epub 2016 Dec 19. ACS Cent Sci. 2017. PMID: 28149952 Free PMC article.
Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.
Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, Cravatt BF. Parker CG, et al. Among authors: felding j. ACS Cent Sci. 2017 Dec 27;3(12):1276-1285. doi: 10.1021/acscentsci.7b00420. Epub 2017 Dec 6. ACS Cent Sci. 2017. PMID: 29296668 Free PMC article.
Divergent synthesis of thapsigargin analogs.
Chu H, Dünstl G, Felding J, Baran PS. Chu H, et al. Among authors: felding j. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2705-2707. doi: 10.1016/j.bmcl.2018.03.065. Epub 2018 Mar 23. Bioorg Med Chem Lett. 2018. PMID: 29636219 Free PMC article.
Divergent Synthesis of Pyrone Diterpenes via Radical Cross Coupling.
Merchant RR, Oberg KM, Lin Y, Novak AJE, Felding J, Baran PS. Merchant RR, et al. Among authors: felding j. J Am Chem Soc. 2018 Jun 20;140(24):7462-7465. doi: 10.1021/jacs.8b04891. Epub 2018 Jun 11. J Am Chem Soc. 2018. PMID: 29921130 Free PMC article.
Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis.
Felding J, Sørensen MD, Poulsen TD, Larsen J, Andersson C, Refer P, Engell K, Ladefoged LG, Thormann T, Vinggaard AM, Hegardt P, Søhoel A, Nielsen SF. Felding J, et al. J Med Chem. 2014 Jul 24;57(14):5893-903. doi: 10.1021/jm500378a. Epub 2014 Jul 1. J Med Chem. 2014. PMID: 24984230 Review.
49 results