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Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation.
Samadder P, Suchánková T, Hylse O, Khirsariya P, Nikulenkov F, Drápela S, Straková N, Vaňhara P, Vašíčková K, Kolářová H, Binó L, Bittová M, Ovesná P, Kollár P, Fedr R, Ešner M, Jaroš J, Hampl A, Krejčí L, Paruch K, Souček K. Samadder P, et al. Among authors: fedr r. Mol Cancer Ther. 2017 Sep;16(9):1831-1842. doi: 10.1158/1535-7163.MCT-17-0018. Epub 2017 Jun 15. Mol Cancer Ther. 2017. PMID: 28619751
BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.
Paculová H, Kramara J, Šimečková Š, Fedr R, Souček K, Hylse O, Paruch K, Svoboda M, Mistrík M, Kohoutek J. Paculová H, et al. Among authors: fedr r. Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479. Tumour Biol. 2017. PMID: 29025359 Free article.
Multiparameter cytometric analysis of complex cellular response.
Šimečková Š, Fedr R, Remšík J, Kahounová Z, Slabáková E, Souček K. Šimečková Š, et al. Among authors: fedr r. Cytometry A. 2018 Feb;93(2):239-248. doi: 10.1002/cyto.a.23295. Epub 2017 Dec 8. Cytometry A. 2018. PMID: 29220555 Free article.
Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.
Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M. Boström J, et al. Among authors: fedr r. PLoS One. 2017 Dec 11;12(12):e0188772. doi: 10.1371/journal.pone.0188772. eCollection 2017. PLoS One. 2017. PMID: 29228002 Free PMC article.
40 results