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Short-Term Therapies for Treatment of Acute and Advanced Heart Failure-Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline?
Pollesello P, Ben Gal T, Bettex D, Cerny V, Comin-Colet J, Eremenko AA, Farmakis D, Fedele F, Fonseca C, Harjola VP, Herpain A, Heringlake M, Heunks L, Husebye T, Ivancan V, Karason K, Kaul S, Kubica J, Mebazaa A, Mølgaard H, Parissis J, Parkhomenko A, Põder P, Pölzl G, Vrtovec B, Yilmaz MB, Papp Z. Pollesello P, et al. Among authors: fedele f. J Clin Med. 2019 Nov 1;8(11):1834. doi: 10.3390/jcm8111834. J Clin Med. 2019. PMID: 31683969 Free PMC article. Review.
Renal effects of levosimendan: a consensus report.
Yilmaz MB, Grossini E, Silva Cardoso JC, Édes I, Fedele F, Pollesello P, Kivikko M, Harjola VP, Hasslacher J, Mebazaa A, Morelli A, le Noble J, Oldner A, Oulego Erroz I, Parissis JT, Parkhomenko A, Poelzl G, Rehberg S, Ricksten SE, Rodríguez Fernández LM, Salmenperä M, Singer M, Treskatsch S, Vrtovec B, Wikström G. Yilmaz MB, et al. Among authors: fedele f. Cardiovasc Drugs Ther. 2013 Dec;27(6):581-90. doi: 10.1007/s10557-013-6485-6. Cardiovasc Drugs Ther. 2013. PMID: 23929366 Free PMC article. Review.
Repetitive use of levosimendan for treatment of chronic advanced heart failure: clinical evidence, practical considerations, and perspectives: an expert panel consensus.
Nieminen MS, Altenberger J, Ben-Gal T, Böhmer A, Comin-Colet J, Dickstein K, Edes I, Fedele F, Fonseca C, García-González MJ, Giannakoulas G, Iakobishvili Z, Jääskeläinen P, Karavidas A, Kettner J, Kivikko M, Lund LH, Matskeplishvili ST, Metra M, Morandi F, Oliva F, Parkhomenko A, Parissis J, Pollesello P, Pölzl G, Schwinger RH, Segovia J, Seidel M, Vrtovec B, Wikström G. Nieminen MS, et al. Among authors: fedele f. Int J Cardiol. 2014 Jun 15;174(2):360-7. doi: 10.1016/j.ijcard.2014.04.111. Epub 2014 Apr 18. Int J Cardiol. 2014. PMID: 24780540 Free article.
The patient perspective: Quality of life in advanced heart failure with frequent hospitalisations.
Nieminen MS, Dickstein K, Fonseca C, Serrano JM, Parissis J, Fedele F, Wikström G, Agostoni P, Atar S, Baholli L, Brito D, Colet JC, Édes I, Gómez Mesa JE, Gorjup V, Garza EH, González Juanatey JR, Karanovic N, Karavidas A, Katsytadze I, Kivikko M, Matskeplishvili S, Merkely B, Morandi F, Novoa A, Oliva F, Ostadal P, Pereira-Barretto A, Pollesello P, Rudiger A, Schwinger RH, Wieser M, Yavelov I, Zymliński R. Nieminen MS, et al. Among authors: fedele f. Int J Cardiol. 2015 Jul 15;191:256-64. doi: 10.1016/j.ijcard.2015.04.235. Epub 2015 May 1. Int J Cardiol. 2015. PMID: 25981363 Free article. Review.
Pharmaco-economics of levosimendan in cardiology: a European perspective.
Nieminen MS, Buerke M, Parissis J, Ben-Gal T, Pollesello P, Kivikko M, Karavidas A, Severino P, Comín-Colet J, Wikström G, Fedele F. Nieminen MS, et al. Among authors: fedele f. Int J Cardiol. 2015 Nov 15;199:337-41. doi: 10.1016/j.ijcard.2015.07.049. Epub 2015 Jul 15. Int J Cardiol. 2015. PMID: 26241640 Free article.
Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper.
Farmakis D, Alvarez J, Gal TB, Brito D, Fedele F, Fonseca C, Gordon AC, Gotsman I, Grossini E, Guarracino F, Harjola VP, Hellman Y, Heunks L, Ivancan V, Karavidas A, Kivikko M, Lomivorotov V, Longrois D, Masip J, Metra M, Morelli A, Nikolaou M, Papp Z, Parkhomenko A, Poelzl G, Pollesello P, Ravn HB, Rex S, Riha H, Ricksten SE, Schwinger RHG, Vrtovec B, Yilmaz MB, Zielinska M, Parissis J. Farmakis D, et al. Among authors: fedele f. Int J Cardiol. 2016 Nov 1;222:303-312. doi: 10.1016/j.ijcard.2016.07.202. Epub 2016 Jul 29. Int J Cardiol. 2016. PMID: 27498374 Free article. Review.
Repetitive use of levosimendan in advanced heart failure: need for stronger evidence in a field in dire need of a useful therapy.
Pölzl G, Altenberger J, Baholli L, Beltrán P, Borbély A, Comin-Colet J, Delgado JF, Fedele F, Fontana A, Fruhwald F, Giamouzis G, Giannakoulas G, Garcia-González MJ, Gustafsson F, Kaikkonen K, Kivikko M, Kubica J, von Lewinski D, Löfman I, Malfatto G, Manito N, Martínez-Sellés M, Masip J, Merkely B, Morandi F, Mølgaard H, Oliva F, Pantev E, Papp Z, Perna GP, Pfister R, Piazza V, Bover R, Rangel-Sousa D, Recio-Mayoral A, Reinecke A, Rieth A, Sarapohja T, Schmidt G, Seidel M, Störk S, Vrtovec B, Wikström G, Yerly P, Pollesello P. Pölzl G, et al. Among authors: fedele f. Int J Cardiol. 2017 Sep 15;243:389-395. doi: 10.1016/j.ijcard.2017.05.081. Epub 2017 May 23. Int J Cardiol. 2017. PMID: 28571618 Free article. Review.
Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post-discharge period.
Pölzl G, Allipour Birgani S, Comín-Colet J, Delgado JF, Fedele F, García-Gonzáles MJ, Gustafsson F, Masip J, Papp Z, Störk S, Ulmer H, Vrtovec B, Wikström G, Altenberger J. Pölzl G, et al. Among authors: fedele f. ESC Heart Fail. 2019 Feb;6(1):174-181. doi: 10.1002/ehf2.12366. Epub 2018 Oct 30. ESC Heart Fail. 2019. PMID: 30378288 Free PMC article. Clinical Trial.
Levosimendan in Acute and Advanced Heart Failure: an Expert Perspective on Posology and Therapeutic Application.
Bouchez S, Fedele F, Giannakoulas G, Gustafsson F, Harjola VP, Karason K, Kivikko M, von Lewinski D, Oliva F, Papp Z, Parissis J, Pollesello P, Pölzl G, Tschöpe C. Bouchez S, et al. Among authors: fedele f. Cardiovasc Drugs Ther. 2018 Dec;32(6):617-624. doi: 10.1007/s10557-018-6838-2. Cardiovasc Drugs Ther. 2018. PMID: 30402660 Free PMC article. Review.
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